Results 61 to 70 of about 2,060 (125)

Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes

Cell Reports, 2015
Telomere-led rapid prophase movements (RPMs) in meiotic prophase have been observed in diverse eukaryote species. A shared feature of RPMs is that the force that drives the chromosomal movements is transmitted from the cytoskeleton, through the nuclear ...
Chih-Ying Lee, Henning F. Horn, Colin L. Stewart, Brian Burke, Ewelina Bolcun-Filas, John C. Schimenti, Michael E. Dresser, Roberto J. Pezza   +7 more
doaj   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Serotonergic Mechanisms of Oocyte Germinal Vesicle Breakdown in the Mud Crab, Scylla paramamosain

Frontiers in Physiology, 2019
The mechanism of serotonin (5-HT)-induced oocyte germinal vesicle breakdown (GVBD) in the mud crab, Scylla paramamosain, was investigated in this study.
Yanan Yang, Dongdong Lin, Chenchang Bao, Huiyang Huang, Haihui Ye   +4 more
doaj   +1 more source

A molecular cytogenetic perspective on chromosome biology and crop improvement

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Bikram S. Gill
wiley   +1 more source

Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response [PDF]

, 2022
Xiaochen Gai, Di Xin, Duo Wu, Xin Wang, Linlin Chen, Yiqing Wang, Kai Ma, Qilin Li, Peng Li, Xiaochun Yu   +9 more
openalex   +1 more source

Efficacy and Acceptability of Licensed and Off‐Label Pharmacological Interventions for Insomnia in Patients With Severe Mental Illness: A Systematic Review and Meta‐Analysis of Randomised Trials

Acta Psychiatrica Scandinavica, Volume 152, Issue 6, Page 405-421, December 2025.
ABSTRACT Background A wide range of drugs is used to alleviate insomnia symptoms in individuals with severe mental illness (SMI), including licensed drugs and sedating drugs prescribed off‐label. Yet, no review has gathered the evidence on illness‐specific or transdiagnostic outcomes of pharmacological interventions for insomnia.
Nina Friis Bak Fuglsang, Nanna Marker Madsen, Søren Lundorff Jacobsen, Julie Eg Frøkjær, Nicolai Ladegaard, Marc Alberg Sørensen, Christoph U. Correll, Christian Otte, Mikkel Højlund, Ole Köhler‐Forsberg   +9 more
wiley   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, Volume 12, Issue 41, November 6, 2025.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, Volume 47, Issue 11, November 2025.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source

Decoding the Molecular Landscape of Prepubertal Oocyte Maturation: GTPBP4 as a Key Driver of In Vitro Developmental Competence

Cell Proliferation, Volume 58, Issue 11, November 2025.
Transcriptional and translational characteristics during goat oocyte maturation and identification of key factors, including GTPBP4, for prepubertal goat oocyte maturation. ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational ...
Jianpeng Qin, Yaozong Wei, Ao Ning, Wenqi Hu, Pengcheng Wan, Beijia Cao, Bo Pan, Tianyi Lv, Kunlin Du, Xueling Yao, Shuqi Zou, Xiangyi Chen, Shengqin Zang, Jiangfeng Ye, Guozhi Yu, Qiuxia Liang, Liuhong Shen, Lin Zhang, Xiang Chen, Keren Cheng, Li Meng, Guangbin Zhou   +21 more
wiley   +1 more source

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Nature Communications
Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
Andreas Heim, Shiya Cheng, Jan Orth, Florian Stengel, Melina Schuh, Thomas U. Mayer   +5 more
doaj   +1 more source