Results 141 to 150 of about 540,753 (335)

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic‐Cell Transplantation

New England Journal of Medicine, 2017
F. Marty, P. Ljungman, R. Chemaly, J. Maertens, S. Dadwal, R. Duarte, S. Haider, A. Ullmann, Y. Katayama, Janice M. Y. Brown, K. Mullane, M. Boeckh, E. Blumberg, H. Einsele, D. Snydman, Y. Kanda, M. Dinubile, V. Teal, H. Wan, Y. Murata, N. Kartsonis, R. Leavitt, C. Badshah   +22 more
semanticscholar   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source

Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass [PDF]

, 2017
Divna Calic, Robert E. Ariano, Rakesh C. Arora, Hilary P. Grocott, Ted M. Lakowski, L. Ryan, Sheryl Zelenitsky   +6 more
openalex   +1 more source

Emicizumab Prophylaxis in Hemophilia A with Inhibitors

New England Journal of Medicine, 2017
J. Oldenburg, J. Mahlangu, Benjamin Kim, C. Schmitt, M. Callaghan, G. Young, E. Santagostino, R. Kruse-Jarres, C. Négrier, C. Kessler, N. Valente, E. Asikanius, G. Levy, J. Windyga, M. Shima   +14 more
semanticscholar   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Comparable relapse incidence after unrelated allogeneic stem cell transplantation with post‐transplant cyclophosphamide versus conventional anti‐graft versus host disease prophylaxis in patients with acute myeloid leukemia: A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation [PDF]

Arnon Nagler, Maud Ngoya, Jacques‐Emmanuel Galimard, Myriam Labopin, Igor Wolfgang Blau, Nicolaus Kröger, Tobias Gedde‐Dahl, Thomas Schroeder, David Burns, Urpu Salmenniemi, Alessandro Rambaldi, Goda Choi, Régis Peffault de Latour, Jan Vydra, Henrik Sengeloev, Matthias Eder, Stephan Mielke, Édouard Forcade, Alexander Kulagin, Fabio Ciceri, Mohamad Mohty   +20 more
openalex   +1 more source

Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.

New England Journal of Medicine, 2012
M. Thigpen, Poloko M. Kebaabetswe, L. Paxton, Dawn K. Smith, C. Rose, Tebogo M. Segolodi, Faith L. Henderson, S. Pathak, F. Soud, K. Chillag, Rodreck Mutanhaurwa, Lovemore Chirwa, M. Kasonde, Daniel Abebe, Evans Buliva, R. Gvetadze, Sandra Johnson, T. Sukalac, Vasavi T. Thomas, C. Hart, Jeffrey A. Johnson, C. Malotte, C. Hendrix, J. Brooks   +23 more
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source