Results 81 to 90 of about 357,093 (268)

Characterization of novel extracellular proteases produced by Acanthamoeba castellanii after contact with human corneal epithelial cells and their relevance to pathogenesis

Parasites & Vectors
Background Proteases produced by Acanthamoeba spp. play an important role in their virulence and may be the key to understanding Acanthamoeba pathogenesis; thus, increasing attention has been directed towards these proteins.
Alvie Loufouma-Mbouaka, Tania Martín-Pérez, Martina Köhsler, Zeynep Danisman, Maya Schwarz, Rounik Mazumdar, Ascel Samba-Louaka, Julia Walochnik   +7 more
doaj   +1 more source

Changes in the Dose–Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant

Dose-Response, 2016
We considered, in general form for a 2 2 full factorial experiment, linear approximations of the organism’s dose–response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A
B. A. Katsnelson, V. G. Panov, A. N. Varaksin, I. A. Minigalieva, L. I. Privalova, M. P. Sutunkova   +5 more
doaj   +1 more source

Antibiotic Prophylaxis for Ocular Surgical Infections

, 2011
Surgical infections are one of the major problems in ophthalmology and can be seen because of many factors, including the conditions of the operating rooms, surgical staff, surgical devices and the patient.
Ufuk Elgin
core   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Bacteraemia Following Different Orthodontic Treatment Procedure

مجلة كلية الطب, 2009
Background: since the occurrence of transient bacteraemia is fatal following different dental procedures in patients at-risk of bacterial endocarditis, the purpose of this research was to estimate the percentage and nature of bacteraemia following four ...
Mustafa M. Al-Khatieeb
doaj   +1 more source

The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children. [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some anti-malarial efficacy.
Tom Hall (712080), Kamija S Phiri, Gondwe, Thandile, Jambo, Kondwani C, Tetteh, Kevin KA, Longwe, Herbert, Chris Drakeley (79962), Wilson L. Mandala (360369), Drakeley, Chris, Kevin K A Tetteh, Phiri, Kamija S, Chris Drakeley, Nyanyiwe Mbeye, Mandala, Wilson L, Nyanyiwe Mbeye (712078), Tom Hall, Kondwani C. Jambo (159487), Kevin K. A. Tetteh (122339), Wilson L Mandala, Thandile Gondwe (712079), Herbert Longwe (712077), Herbert Longwe, Thandile Gondwe, Mbeye, Nyanyiwe, Kamija S. Phiri (52377), Hall, Tom, Kondwani C Jambo   +26 more
core   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Role of systemic antibiotic prophylaxis in acute burns: A retrospective analysis from a tertiary care center

, 2020
Introduction: Burns is a worldwide problem, majority of them occurs in low and middle-income countries. The hurdles in treatment of burns in the resource restricted setting are much unique and challenging.
Arumugam, Praveen Kumar, Muthukumar, Vamseedharan, Bamal, Rahul   +2 more
core   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

The Possible Role of Antibodies in Alopecia: A Narrative Review

Antibodies
Human hair performs a number of important physiological and esthetic functions. Hair loss and alopecia are complex disorders which affect people all over the world. Hair loss can be an early manifestation of various autoimmunological disorders. Despite a
Julia Cieślawska, Mariola Pawlaczyk, Justyna Gornowicz-Porowska   +2 more
doaj   +1 more source