Results 1 to 10 of about 50,649 (116)

Alpha7 nicotinic acetylcholine receptor activation attenuates allergic airway inflammation and is associated with heme oxygenase-1 induction [PDF]

Frontiers in Immunology
BackgroundActivation of the α7 nicotinic acetylcholine receptor (α7nAChR) exerts anti-inflammatory effects; however, its role in allergic airway inflammation remains poorly understood. This study investigated how GTS-21 treatment, consistent with α7nAChR
Jun Iriki, Jun Iriki, Susumu Fukahori, Yasushi Obase, Yasushi Obase, Yasuna Nakamura, Ryusuke Umene, Ryusuke Umene, Chia-Hsien Wu, Yuri Yamada, Yuri Yamada, Shinnosuke Takemoto, Takahiro Takazono, Takahiro Takazono, Noriho Sakamoto, Chizu Fukushima, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae, Hiroshi Mukae, Tsuyoshi Inoue   +20 more
doaj   +2 more sources

Tackling Allergic Airway Inflammation with Organic Sheet‐Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles [PDF]

Advanced Science
Allergic airway inflammatory disorders, such as allergic rhinitis (AR) and asthma, affect the health of more than one billion people worldwide, yet therapeutic outcomes remain unsatisfactory.
Zhaoxu Tu, Junyan Lin, Zhixin Li, Yuefei Zhu, Changyi Xu, Zihan Qiu, Qiumin Wang, Yang Ye, Yihui Wen, Jian Li, Kam W. Leong, Weiping Wen   +11 more
doaj   +2 more sources

Oncostatin M Drives Th2 Polarized Allergic Airway Inflammation Through Fibroblast Reprogramming and Endoplasmic Reticulum Stress [PDF]

International Journal of Nanomedicine
Huanping Zhang,1,* Xiaoxue Chen,1,* Le Liu,2 Haoyue Zheng,2 Xing Yang,1 Kai Yin,1 Qi Yao,1 Lei Li,1 Pingchang Yang2 1Department of Allergy Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital ...
Zhang H, Chen X, Liu L, Zheng H, Yang X, Yin K, Yao Q, Li L, Yang P   +8 more
doaj   +2 more sources

IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation

Cell Reports, 2019
Summary: Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma.
Juan He, Qiong Yang, Qiang Xiao, Aihua Lei, Xing Li, Pan Zhou, Ting Liu, Lijuan Zhang, Kun Shi, Quan Yang, Junchao Dong, Jie Zhou   +11 more
doaj   +3 more sources

Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1

Allergology International, 2022
Background: Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including Th2 cells and ILC2s.
Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima   +9 more
doaj   +1 more source

Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy

Frontiers in Immunology, 2022
RationaleAryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered as an important regulator for immune diseases. We have previously shown that AhR protects against allergic airway inflammation.
Ji Wang, Ji Wang, Ji Wang, Yilin Zhao, Yilin Zhao, Xin Zhang, Xin Zhang, Wei Tu, Wei Tu, Rongjun Wan, Rongjun Wan, Yingchun Shen, Yan Zhang, Yan Zhang, Ruchik Trivedi, Peisong Gao   +15 more
doaj   +1 more source

Exosomes Derived from Dermatophagoides farinae Induce Allergic Airway Inflammation

Microbiology Spectrum, 2023
House dust mites (HDMs) are a major source of indoor allergens that cause airway allergic disease. Dermatophagoides farinae, a predominant species of HDMs in China, has demonstrated pathogenic role in allergic disorders.
Ting Yang, Zuyu Xu, Jinyan Yu, Jiaxi Liu, Wei Wang, Shanchao Hong   +5 more
doaj   +1 more source

Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease

Frontiers in Immunology, 2023
BackgroundAsthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts.
Sebastian Reuter, Jonas Raspe, Hendrik Uebner, Alexandros Contoyannis, Eva Pastille, Astrid M. Westendorf, Georgia C. Caso, Timothy L. Cover, Timothy L. Cover, Anne Müller, Christian Taube   +10 more
doaj   +1 more source

Cytokine-induced killer cells: A novel treatment for allergic airway inflammation. [PDF]

PLoS ONE, 2017
The effectiveness of cytokine-induced killer (CIK) cells for treatment of cancers has long been appreciated. Here, we report for the first time that CIK cells can be applied to treat allergic airway inflammation.
Panwadee Pluangnooch, Sunita Timalsena, Adisak Wongkajornsilp, Kitipong Soontrapa   +3 more
doaj   +1 more source

Blockade of Tyrosine Kinase, LCK Leads to Reduction in Airway Inflammation through Regulation of Pulmonary Th2/Treg Balance and Oxidative Stress in Cockroach Extract-Induced Mouse Model of Allergic Asthma

Metabolites, 2022
Asthma is one of the most common inflammatory diseases affecting the airways. Approximately 300 million individuals suffer from asthma around the world.
Saleh A. Alqarni, Abdulwahab Bineid, Sheikh F. Ahmad, Naif O. Al-Harbi, Faleh Alqahtani, Khalid E. Ibrahim, Nemat Ali, Ahmed Nadeem   +7 more
doaj   +1 more source