Results 41 to 50 of about 936,865 (297)
Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. [PDF]
PLoS ONE, 2011 Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling and fibrosis but the mechanisms involved are not clear.
Jill R Johnson +4 more
doaj +1 more source
Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes [PDF]
, 2013 Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non ...
Pascale Kippelen +14 more
core +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Parasites & Vectors, 2022 Background There is ample evidence demonstrating a reverse relationship between helminth infection and immune-mediated diseases. Accordingly, several studies have shown that Echinococcus granulosus infection and hydatid cyst compounds are able to ...
Sara Ghabdian +3 more
doaj +1 more source
Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]
, 2014 Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core +1 more source
Activation and regulation of chemokines in allergic airway inflammation [PDF]
Journal of Leukocyte Biology, 1996 Abstract Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airway. The initial induction of immunoglobulin E (IgE)-mediated mast cell degranulation, up-regulation of adhesion molecules, and the production of inflammatory and chemotactic cytokines, leading to the ...
Lukacs, N.W. +3 more
openaire +3 more sources
Dimethyl fumarate abrogates dust mite‐induced allergic asthma by altering dendritic cell function
Immunity, Inflammation and Disease, 2019 Introduction Allergic asthma is the most common inflammatory disease of upper airways. Airway dendritic cells (DCs) are key antigen presenting cells that regulate T helper 2 (Th2)‐dependent allergic inflammation.
Anil K. Jaiswal +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Toll-like receptor 2 (TLR2) is suggested to initiate the activation of NLRP3 inflammasome, and considered to be involved in asthma. The findings that melatonin modulates TLRs-mediated immune responses, together with the suppressing effect of TLRs on ...
Hui-Mei Wu +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Allergic airway inflammation is a universal airway disease that is driven by hyperresponsiveness to inhaled allergens. Group 2 innate lymphoid cells (ILC2s) produce copious amounts of type 2 cytokines, which lead to allergic airway inflammation. Here, we
Xiaogang Zhang +12 more
doaj +1 more source
CD69 Controls the Pathogenesis of Allergic Airway Inflammation [PDF]
The Journal of Immunology, 2009 Abstract Airway inflammation and airway hyperresponsiveness are central issues in the pathogenesis of asthma. CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In CD69-deficient
Takako, Miki-Hosokawa +11 more
openaire +2 more sources