Results 61 to 70 of about 936,865 (297)

Therapeutic potential of a phospholipase D1 inhibitory peptide fused with a cell-penetrating peptide as a novel anti-asthmatic drug in a Der f 2-induced airway inflammation model

Experimental and Molecular Medicine, 2018
Allergic asthma: Drug to tackle allergy-triggered inflammation A drug that targets a key enzyme involved in airway tissue inflammation shows promise in the treatment of allergic asthma.
Yun Young Lee, So Young Lee, Shin-Young Park, Hye-Jin Choi, Eung-Gook Kim, Joong-Soo Han   +5 more
doaj   +1 more source

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation [PDF]

The Journal of Immunology, 2015
Abstract Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propagate the adaptive immune response associated with allergic airway inflammation in asthma. Activation of the transcription factor NF-κB in AECs by allergens or secondary mediators via G protein–coupled receptors (GPCRs) is an important ...
Benjamin, Causton, Ravisankar A, Ramadas, Josalyn L, Cho, Khristianna, Jones, Ana, Pardo-Saganta, Jayaraj, Rajagopal, Ramnik J, Xavier, Benjamin D, Medoff   +7 more
openaire   +2 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Cell-type-specific role of P2Y2 receptor in HDM-driven model of allergic airway inflammation

Frontiers in Immunology, 2023
Allergic airway inflammation (AAI) is a chronic respiratory disease that is considered a severe restriction in daily life and is accompanied by a constant risk of acute aggravation.
Dominik Schneble, Ahmed El-Gazzar, Zahra Kargarpour, Markus Kramer, Seda Metekol, Slagjana Stoshikj, Marco Idzko, Marco Idzko   +7 more
doaj   +1 more source

Measurement of airway function using invasive and non-invasive methodsin mild and severe models for allergic airway inflammation in mice [PDF]

, 2014
In this study a direct comparison was made between non-invasive and non-ventilated unrestrained whole body plethysmography (Penh) (conscious animals) and the invasive ventilated lung resistance (RL) method (anaesthetized animals) in both mild and severe ...
Johan eGarssen, Kim eVerheijden, Frank A Redegeld, Verheijden, Kim A T, Paul A. J. Henricks, Garssen, Johan, Pharmacology, Gert Folkerts, Sub Immunopharmacology, Sub Airway in vivo Pharmacology, Kim A. T. Verheijden, Redegeld, Frank A., Henricks, Paul A J, Frank A. Redegeld, Paul eHenricks, Folkerts, Gert, Gert eFolkerts, UIPS - Utrecht Institute for Pharmaceutical Sciences, Johan Garssen   +18 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Mitochondrial Dysfunction Increases Allergic Airway Inflammation [PDF]

The Journal of Immunology, 2009
Abstract The prevalence of allergies and asthma among the world’s population has been steadily increasing due to environmental factors. It has been described that exposure to ozone, diesel exhaust particles, or tobacco smoke exacerbates allergic inflammation in the lungs.
Leopoldo, Aguilera-Aguirre, Attila, Bacsi, Alfredo, Saavedra-Molina, Alexander, Kurosky, Sanjiv, Sur, Istvan, Boldogh   +5 more
openaire   +2 more sources

Differential Regulation of Allergic Airway Inflammation by Acetylcholine

Frontiers in Immunology, 2022
Acetylcholine (ACh) from neuronal and non-neuronal sources plays an important role in the regulation of immune responses and is associated with the development of several disease pathologies. We have previously demonstrated that group 2 innate lymphoid cell (ILC2)-derived ACh is required for optimal type 2 responses to parasitic infection and therefore
Luke B. Roberts, Luke B. Roberts, Rita Berkachy, Madina Wane, Dhiren F. Patel, Corinna Schnoeller, Graham M. Lord, Graham M. Lord, Kleoniki Gounaris, Bernhard Ryffel, Valerie Quesniaux, Matthew Darby, William G. C. Horsnell, William G. C. Horsnell, William G. C. Horsnell, Murray E. Selkirk   +15 more
openaire   +5 more sources

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Allergen immunotherapy combined with Notch pathway inhibitors improves HDM-induced allergic airway inflammation and inhibits ILC2 activation

Frontiers in Immunology
IntroductionGroup 2 innate lymphoid cells (ILC2s) play a crucial role in house dust mite (HDM)-induced allergic inflammation, and allergen immunotherapy (AIT) holds promise for treating the disease by reducing the frequency of ILC2s.
Yu Tong, Lei Wang, Lingya Wang, Jingjing Song, Junwen Fan, Chuqiao Lai, Jiali Bao, Cuiye Weng, Yufei Wang, Jilong Shuai, Hui Zhang, Weixi Zhang   +11 more
doaj   +1 more source