Results 51 to 60 of about 50,798 (264)

Cytokine and Chemokine Interactions in Allergic Airway Inflammation [PDF]

ILAR Journal, 1999
Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airway. The development of appropriate animal models to dissect the critical mechanisms involved in the deleterious responses is crucial for the evolution of proper therapeutic approaches.
Emma M., Campbell, Nicholas W., Lukacs
openaire   +2 more sources

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Allergen immunotherapy combined with Notch pathway inhibitors improves HDM-induced allergic airway inflammation and inhibits ILC2 activation

Frontiers in Immunology
IntroductionGroup 2 innate lymphoid cells (ILC2s) play a crucial role in house dust mite (HDM)-induced allergic inflammation, and allergen immunotherapy (AIT) holds promise for treating the disease by reducing the frequency of ILC2s.
Yu Tong, Lei Wang, Lingya Wang, Jingjing Song, Junwen Fan, Chuqiao Lai, Jiali Bao, Cuiye Weng, Yufei Wang, Jilong Shuai, Hui Zhang, Weixi Zhang   +11 more
doaj   +1 more source

Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation

Clinical and Translational Medicine, 2021
Rhinovirus (RV) infections are associated with asthma exacerbations. MicroRNA‐146a and microRNA‐146b (miR‐146a/b) are anti‐inflammatory miRNAs that suppress signaling through the nuclear factor kappa B (NF‐κB) pathway and inhibit pro‐inflammatory ...
Anet Laanesoo, Egon Urgard, Kapilraj Periyasamy, Martti Laan, Yury A. Bochkov, Alar Aab, Nathaniel Magilnick, Margus Pooga, James E. Gern, Sebastian L. Johnston, Jonathan M. Coquet, Mark P. Boldin, Jesper Wengel, Alan Altraja, Grazyna Bochenek, Bogdan Jakiela, Ana Rebane   +16 more
doaj   +1 more source

Multi-Faceted Notch in Allergic Airway Inflammation [PDF]

International Journal of Molecular Sciences, 2019
Notch is an evolutionarily conserved signaling family which iteratively exerts pleiotropic functions in cell fate decisions and various physiological processes, not only during embryonic development but also throughout adult life. In the context of the respiratory system, Notch has been shown to regulate ciliated versus secretory lineage ...
Huang, Miao-Tzu, Chiu, Chiao-Juno, Chiang, Bor-Luen   +2 more
openaire   +2 more sources

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. [PDF]

PLoS ONE, 2013
Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. However, the initiating factor that links airway inflammation to remodeling is unknown.
Zhuang-Gui Chen, Tian-Tuo Zhang, Hong-Tao Li, Fen-Hua Chen, Xiao-Ling Zou, Jing-Zhi Ji, Hong Chen   +6 more
doaj   +1 more source

Pharmacological blockade of protease-Activated Receptor 2 improves airway remodeling and lung inflammation in experimental allergic asthma

Brazilian Journal of Pharmaceutical Sciences, 2023
Protease-activated receptors (PARs) are metabotropic G-protein-coupled receptors that are activated via proteolytic cleavage of a specific sequence of amino acids in their N-terminal region.
Natália Alves de Matos, Diego Carlos dos Reis, Lucas Kraemer Rocha, Matheus Silvério de Mattos, Geovanni Dantas Cassali, Remo Castro Russo, Andrea de Castro Perez, André Klein   +7 more
doaj   +1 more source

Cytokines in Allergic Eosinophilic Airway Inflammation

Neurosignals, 1996
Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airways. The development of appropriate animal models to dissect the critical mechanisms involved in the deleterious responses is crucial for the development of proper therapeutic approaches.
openaire   +2 more sources

Experimental advances in understanding allergic airway inflammation [PDF]

Frontiers in Bioscience, 2013
Asthma is largely an inflammatory disease, with the development of T cell mediated inflammation in the lung following exposure to allergen or other precipitating factors. Currently, the major therapies for this disease are directed either at relief of bronchoconstriction (ie beta-agonists) or are non-specific immunomodulators (ie, corticosteroids ...
Christine M, Deppong, Jonathan M, Green
openaire   +2 more sources