Results 31 to 40 of about 50,798 (264)

CD69 Controls the Pathogenesis of Allergic Airway Inflammation [PDF]

The Journal of Immunology, 2009
Abstract Airway inflammation and airway hyperresponsiveness are central issues in the pathogenesis of asthma. CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In CD69-deficient
Takako, Miki-Hosokawa, Akihiro, Hasegawa, Chiaki, Iwamura, Kenta, Shinoda, Soichi, Tofukuji, Yukiko, Watanabe, Hiroyuki, Hosokawa, Shinichiro, Motohashi, Kahoko, Hashimoto, Mutsunori, Shirai, Masakatsu, Yamashita, Toshinori, Nakayama   +11 more
openaire   +2 more sources

Exacerbation of allergic asthma by somatic antigen of Echinococcus granulosus in allergic airway inflammation in BALB/c mice

Parasites & Vectors, 2022
Background There is ample evidence demonstrating a reverse relationship between helminth infection and immune-mediated diseases. Accordingly, several studies have shown that Echinococcus granulosus infection and hydatid cyst compounds are able to ...
Sara Ghabdian, Sima Parande Shirvan, Mohsen Maleki, Hassan Borji   +3 more
doaj   +1 more source

Differential Regulation of Allergic Airway Inflammation by Acetylcholine

Frontiers in Immunology, 2022
Acetylcholine (ACh) from neuronal and non-neuronal sources plays an important role in the regulation of immune responses and is associated with the development of several disease pathologies. We have previously demonstrated that group 2 innate lymphoid cell (ILC2)-derived ACh is required for optimal type 2 responses to parasitic infection and therefore
Luke B. Roberts, Luke B. Roberts, Rita Berkachy, Madina Wane, Dhiren F. Patel, Corinna Schnoeller, Graham M. Lord, Graham M. Lord, Kleoniki Gounaris, Bernhard Ryffel, Valerie Quesniaux, Matthew Darby, William G. C. Horsnell, William G. C. Horsnell, William G. C. Horsnell, Murray E. Selkirk   +15 more
openaire   +5 more sources

Endothelin-A Receptor Antagonist Alleviates Allergic Airway Inflammation via the Inhibition of ILC2 Function

Frontiers in Immunology, 2022
Allergic airway inflammation is a universal airway disease that is driven by hyperresponsiveness to inhaled allergens. Group 2 innate lymphoid cells (ILC2s) produce copious amounts of type 2 cytokines, which lead to allergic airway inflammation. Here, we
Xiaogang Zhang, Ziyang Chen, Shaowen Zuo, Hengbiao Sun, Xinyao Li, Xiao Lu, Zhe Xing, Meiqi Chen, Jingping Liu, Gang Xiao, Yumei He, Yumei He, Yumei He   +12 more
doaj   +1 more source

Dimethyl fumarate abrogates dust mite‐induced allergic asthma by altering dendritic cell function

Immunity, Inflammation and Disease, 2019
Introduction Allergic asthma is the most common inflammatory disease of upper airways. Airway dendritic cells (DCs) are key antigen presenting cells that regulate T helper 2 (Th2)‐dependent allergic inflammation.
Anil K. Jaiswal, Maninder Sandey, Amol Suryawanshi, Russell C. Cattley, Amarjit Mishra   +4 more
doaj   +1 more source

MTOR-Mediated Autophagy Is Involved in the Protective Effect of Ketamine on Allergic Airway Inflammation

Journal of Immunology Research, 2019
Unresolved inflammation underpins the pathogenesis of allergic airway diseases, such as asthma. Ketamine, accepted as a promising therapy for resistant asthma, has been demonstrated to attenuate allergic airway inflammation.
Hongyun Zou, Li-Xia Wang, Muzi Wang, Cheng Cheng, Shuai Li, Qiying Shen, Lei Fang, Rongyu Liu   +7 more
doaj   +1 more source

Impacts of allergic airway inflammation on lung pathology in a mouse model of influenza A virus infection. [PDF]

PLoS ONE, 2017
Influenza A virus is the respiratory pathogen responsible for influenza. Infection by the 2009 pandemic influenza A (H1N1) virus caused severe lower airway inflammation and pneumonia.
Akira Kawaguchi, Tadaki Suzuki, Yuki Ohara, Kenta Takahashi, Yuko Sato, Akira Ainai, Noriyo Nagata, Masato Tashiro, Hideki Hasegawa   +8 more
doaj   +1 more source

Caspase-11 promotes allergic airway inflammation [PDF]

Nature Communications, 2020
Abstract Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill   +21 more
openaire   +5 more sources

Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. [PDF]

PLoS ONE, 2017
C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined ...
Fanny Ender, Anna V Wiese, Inken Schmudde, Jing Sun, Tillman Vollbrandt, Peter König, Yves Laumonnier, Jörg Köhl   +7 more
doaj   +1 more source

Activation and regulation of chemokines in allergic airway inflammation [PDF]

Journal of Leukocyte Biology, 1996
Abstract Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airway. The initial induction of immunoglobulin E (IgE)-mediated mast cell degranulation, up-regulation of adhesion molecules, and the production of inflammatory and chemotactic cytokines, leading to the ...
Lukacs, N.W., Strieter, R.M., Chensue, S.W., Kunkel, S.L.   +3 more
openaire   +3 more sources