Results 21 to 30 of about 50,798 (264)

Ambient ozone, and urban PM2.5 co-exposure, aggravate allergic asthma via transient receptor potential vanilloid 1-mediated neurogenic inflammation

Ecotoxicology and Environmental Safety, 2022
Allergic asthma is the most common pulmonary inflammatory disease, and epidemiological studies have revealed that PM2.5 or ambient ozone (O3) exposure contribute to the higher prevalence of allergic asthma. Current experimental evidence focus principally
Zongpei Lian, Haomin Qi, Xudong Liu, Yuchao Zhang, Ruijia Xu, Xu Yang, Yan Zeng, Jinquan Li   +7 more
doaj   +1 more source

Allergic Airway Inflammation [PDF]

, 2012
Allergic airway inflammation is one characteristic feature of asthma disease, with additional pathology including a reversible airway obstruction, airway hyperresponsiveness (AHR), infiltration of eosinophils and T-helper type 2 (Th2) cells into the airway submucosa, mucus hypersecretion, and airway remodeling (Agrawal & Shao 2010).
Gabriel Morn, Claudio Henriquez, Hugo Folch   +2 more
openaire   +1 more source

Nox enzymes in allergic airway inflammation [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2011
Chronic airway diseases such as asthma are linked to oxidative environmental factors and are associated with increased production of reactive oxygen species (ROS). Therefore, it is commonly assumed that oxidative stress is an important contributing factor to asthma disease pathogenesis and that antioxidant strategies may be useful in the treatment of ...
openaire   +2 more sources

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

Frontiers in Genetics, 2020
BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of the ...
Peter McErlean, Peter McErlean, Audrey Kelly, Audrey Kelly, Jaideep Dhariwal, Jaideep Dhariwal, Max Kirtland, Max Kirtland, Julie Watson, Julie Watson, Ismael Ranz, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Roberto Solari, Michael R. Edwards, Michael R. Edwards, Sebastian L. Johnston, Sebastian L. Johnston, Paul Lavender, Paul Lavender   +24 more
doaj   +1 more source

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease

Respiratory Research, 2022
Background Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function. In the context
Rebecca Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms, Jill R. Johnson   +5 more
doaj   +1 more source

Roles of IL-22 in Allergic Airway Inflammation [PDF]

Journal of Allergy, 2013
IL-23- and IL-17A-producing CD4+ T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells,
Koichi Hirose, Kentaro Takahashi, Hiroshi Nakajima   +2 more
openaire   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. [PDF]

PLoS ONE, 2011
Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling and fibrosis but the mechanisms involved are not clear.
Jill R Johnson, Abraham Roos, Tove Berg, Magnus Nord, Jonas Fuxe   +4 more
doaj   +1 more source

Neural regulation of ILC2s in allergic airway inflammation

Frontiers in Allergy, 2023
The sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) regulate the effector functions of group 2 innate lymphoid cells (ILC2s) through β2 adrenergic receptor (ADRB2) and nicotinic/muscarinic cholinergic receptor signaling, respectively.
Christopher M. Thomas, R. Stokes Peebles, R. Stokes Peebles, R. Stokes Peebles   +3 more
openaire   +3 more sources

TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation

Frontiers in Immunology, 2020
Toll-like receptor 2 (TLR2) is suggested to initiate the activation of NLRP3 inflammasome, and considered to be involved in asthma. The findings that melatonin modulates TLRs-mediated immune responses, together with the suppressing effect of TLRs on ...
Hui-Mei Wu, Hui-Mei Wu, Cui-Cui Zhao, Cui-Cui Zhao, Qiu-Meng Xie, Qiu-Meng Xie, Juan Xu, Juan Xu, Guang-He Fei   +8 more
doaj   +1 more source