Results 11 to 20 of about 936,865 (297)

Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Molecular Therapy: Nucleic Acids, 2016
Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17 ...
Yi-Lien Chen, Bor-Luen Chiang
doaj   +2 more sources

Caspase-11 promotes allergic airway inflammation [PDF]

Nature Communications, 2020
Abstract Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill   +21 more
openaire   +6 more sources

Effect of Ozone on Allergic Airway Inflammation [PDF]

05.03 - Allergy and immunology, 2022
ABSTRACT Background Exposure to O 3 has been associated with increased risk of exacerbations of asthma, but the underlying mechanisms are not well studied.
Mehrdad Arjomandi, Hofer Wong, Rachel Tenney, Nina Holland, John R. Balmes   +4 more
openaire   +4 more sources

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype [PDF]

, 2013
We previously demonstrated inhibition of ovalbumin (OVA)-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae.
Harnett, M.M., Coltherd, Jennifer C., Harnett, W., Kean, Dorothy, Lamyaa Al-Riyami, Harnett, Margaret, Coltherd, Jennifer, Jennifer C. Coltherd, Steiger, Christina, Christina N. Steiger, Siebeke, I., Harnett, William, Coltherd, J.C., McSharry, Charles, Siebeke, Ivonne, Margaret M. Harnett, Al-Riyami, L., Justyna Rzepecka, Steiger, C.N., William Harnett, Dorothy E. Kean, Al-Riyami, Lamyaa, Harnett, Margaret M., Steiger, Christina N., Charles McSharry, Kean, Dorothy E., Rzepecka, J., Kean, D.E., Rzepecka, Justyna, McSharry, C., Ivonne Siebeke   +30 more
core   +4 more sources

Pathogenesis of Allergic Airway Inflammation [PDF]

Current Allergy and Asthma Reports, 2009
Advances have been made in defining the mechanisms for the control of allergic airway inflammation in response to inhaled antigens. Several genes, including ADAM33, DPP10, PHF11, GPRA, TIM-1, PDE4D, OPN3, and ORMDL3, have been implicated in the pathogenesis and susceptibility to atopy and asthma.
Devendra K, Agrawal, Zhifei, Shao
openaire   +2 more sources

Blockade of Tyrosine Kinase, LCK Leads to Reduction in Airway Inflammation through Regulation of Pulmonary Th2/Treg Balance and Oxidative Stress in Cockroach Extract-Induced Mouse Model of Allergic Asthma

Metabolites, 2022
Asthma is one of the most common inflammatory diseases affecting the airways. Approximately 300 million individuals suffer from asthma around the world.
Saleh A. Alqarni, Abdulwahab Bineid, Sheikh F. Ahmad, Naif O. Al-Harbi, Faleh Alqahtani, Khalid E. Ibrahim, Nemat Ali, Ahmed Nadeem   +7 more
doaj   +1 more source

Spatial characteristics of neutrophils and eosinophils in conducting airway mucosa of mice with induced allergic airway inflammation

Медицинская иммунология, 2023
Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko, D. E. Murova, E. A. Servuli   +2 more
doaj   +1 more source

The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma

Respiratory Research, 2020
Background The interleukin 17 receptor E (IL-17RE) is specific for the epithelial cytokine interleukin-17C (IL-17C). Asthma exacerbations are frequently caused by viral infections.
Giovanna Vella, Lars Lunding, Felix Ritzmann, Anja Honecker, Christian Herr, Michael Wegmann, Robert Bals, Christoph Beisswenger   +7 more
doaj   +1 more source

Airway Fibrinogenolysis and the Initiation of Allergic Inflammation [PDF]

Annals of the American Thoracic Society, 2014
Abstract The past 15 years of allergic disease research have produced extraordinary improvements in our understanding of the pathogenesis of airway allergic diseases such as asthma. Whereas it was previously viewed as largely an immunoglobulin E-mediated process, the gradual recognition that T cells, especially Type 2 T helper (Th2 ...
Valentine Ongeri, Millien, Wen, Lu, Garbo, Mak, Xiaoyi, Yuan, J Morgan, Knight, Paul, Porter, Farrah, Kheradmand, David B, Corry   +7 more
openaire   +2 more sources

The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation

Cell Reports, 2016
Allergic airway inflammation is one of the primary features of allergic asthma. Interleukin-33 (IL-33) is recognized as a key pro-inflammatory cytokine that mediates allergic airway inflammation, and its expression is elevated in this condition, but ...
Yusuke Yamazumi, Oh Sasaki, Mitsuru Imamura, Takeaki Oda, Yoko Ohno, Yumi Shiozaki-Sato, Shigenori Nagai, Saki Suyama, Yuki Kamoshida, Kosuke Funato, Teruhito Yasui, Hitoshi Kikutani, Kazuhiko Yamamoto, Makoto Dohi, Shigeo Koyasu, Tetsu Akiyama   +15 more
doaj   +1 more source