Results 71 to 80 of about 50,798 (264)

Role of immunoglobulin E and mast cells in murine models of asthma

Brazilian Journal of Medical and Biological Research, 2003
Immunoglobulin E (IgE) and mast cells are believed to play important roles in allergic inflammation. However, their contributions to the pathogenesis of human asthma have not been clearly established.
S.I. Mayr, R.I. Zuberi, F.-T. Liu
doaj   +1 more source

A pathophysiological role of PDE3 in allergic airway inflammation [PDF]

JCI Insight, 2018
Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans.
Beute, Jan, Lukkes, Melanie, Koekoek, Ewout P., Nastiti, Hedwika, Ganesh, Keerthana, de Bruijn, Marjolein J.W., Hockman, Steve, van Nimwegen, Menno, Braunstahl, Gert-Jan, Boon, Louis, Lambrecht, Bart N., Manganiello, Vince C., Hendriks, Rudi W., KleinJan, Alex   +13 more
openaire   +2 more sources

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

The airway neuro-immune axis as a therapeutic target in allergic airway diseases

Respiratory Research
Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma and allergic rhinitis.
Wanhua Wu, Jianing Li, Su Chen, Suidong Ouyang   +3 more
doaj   +1 more source

Comparative transcriptional profiling of key macrophage and fibroblast subpopulations in rheumatoid arthritis‐associated lung disease

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Myeloid differentiation-2 is a potential biomarker for the amplification process of allergic airway sensitization in mice

Allergology International, 2015
Background: Allergic sensitization is a key step in the pathogenesis of asthma. However, little is known about the molecules that are critical regulators for establishing allergic sensitization of the airway.
Daisuke Koyama, Shuichiro Maruoka, Yasuhiro Gon, Yoshitaka Shintani, Tadataka Sekiyama, Hisato Hiranuma, Sotaro Shikano, Kazumichi Kuroda, Ikuko Takeshita, Eriko Tsuboi, Kaori Soda, Shu Hashimoto   +11 more
doaj   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source