Results 171 to 180 of about 4,219 (248)

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Emerging Therapeutics for Primary Biliary Cholangitis. [PDF]

Korean J Gastroenterol
Cho EJ.
europepmc   +1 more source

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, EarlyView.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

Synthesis of p-Coumarates With Potential Anti-Alzheimer's Action: Enzyme Inhibition and In Silico Studies. [PDF]

Chem Biodivers
Lopes SP, Emídio JJ, Duarte ABS, Orhan IE, Deniz FSS, Salmas RE, de Sousa DP.   +6 more
europepmc   +1 more source

Maternal Perinatal Gut Microbiome Is Shaped by Traditional Farming Lifestyle and Associated With Early Childhood Atopic Disease

Allergy, EarlyView.
We assessed whether the maternal perinatal gut microbiome and serum SCFA and cord blood SCFA differ between traditional farming and urban dyads. Women following a farming lifestyle had increased microbial diversity, several differentially abundant bacterial species and functional pathways, and increased circulating SCFA. Overall maternal gut microbiome
Erin C. Davis, Courtney M. Jackson, Nichole S. Diaz, Jazmine Susana, Ashley Nelson, Richard Insel, Antti E. Seppo, Kirsi M. Järvinen   +7 more
wiley   +1 more source

Site-Selective Activation and Stereospecific Functionalization of Bis(boronic Esters) Derived from 2-Alkenes: Construction of Propionates and Other 1,2-Difunctional Motifs. [PDF]

Angew Chem Int Ed Engl
Xu N, Holmgren JL, Morken JP.
europepmc   +1 more source

Dietary Habits and Atopic Dermatitis Significantly Influence the Fecal Microbiome

Allergy, EarlyView.
Atopic dermatitis, dietary habits, sex, and BMI significantly influenced the fecal microbiome composition. On the species level, Faecalibacterium taiwanense was more abundant in atopic dermatitis, and Vescimonas sp000435555 was more abundant in the control population. On the genus level, CAG‐302 (NCBI: Clostridium) was more abundant in controls.
Danielle Fehr, Nicole Flack, Gloria Masenga, Nelson Mosha, Nick Li, Anna White, George Semango, Meike Distler, Claudia Lang, Felix Grimm, Michael Scharl, Daudi Mavura, John Elisante Masenga, Peter Schmid‐Grendelmeier, Marie‐Charlotte Brüggen   +14 more
wiley   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Propionate metabolism is dysregulated in non-small cell lung cancer patients and EGFR-mutant drug-tolerant persister cells. [PDF]

Sci Rep
Parang B, Yoffe L, Khan R, Li Z, Nagiec MJ, Gardner EE, Shieh Y, Heise RS, Saxena A, Altorki N, Blenis J.   +10 more
europepmc   +1 more source

In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy

Acta Paediatrica, EarlyView.
ABSTRACT Aim Research on the drug delivery of inhaled corticosteroids and combination medications via valved holding chambers (VHCs) with children's breathing patterns is limited. We aimed to evaluate the in vitro performance of commercially available VHCs without facemasks under preschooler breathing conditions, focusing on total delivered dose and ...
Laura Ojanperä, Lauri Lehtimäki, Péter Csonka   +2 more
wiley   +1 more source