Results 1 to 10 of about 160,037 (356)

Pharmacokinetic models for propofol—defining and illuminating the devil in the detail [PDF]

British Journal of Anaesthesia, 2009
The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting. With effect-site targeting the goal is to achieve a user-defined target effect-site
Absalom, A.R., De Smet, Tom, Mani, V., Struys, Michel   +3 more
exaly   +13 more sources

Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report. [PDF]

SAGE Open Med Case Rep
Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic ...
Zhang H, Liu Y, Liu M, Li B, Li H.
europepmc   +2 more sources

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Use of remifentanil to reduce propofol injection pain and the required propofol dose in upper digestive tract endoscopy diagnostic tests [PDF]

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The introduction of propofol (2,6-diisopropylphenol) as a sedative agent has transformed the area of sedation for endoscopic procedures.
Gustavo Nadal Uliana, Elizabeth Milla Tambara, Giorgio Alfredo Pedroso Baretta   +2 more
doaj   +6 more sources

Esketamine improves propofol-induced brain injury and cognitive impairment in rats

Translational Neuroscience, 2022
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of
Xu Guiping, Wang Yang, Chen Zhe, Zhang Yuxuan, Zhang Xuexue, Zhang Guichao   +5 more
doaj   +1 more source

The propofol-sparing effect of intravenous lidocaine in elderly patients undergoing colonoscopy: a randomized, double-blinded, controlled study

BMC Anesthesiology, 2020
Background Propofol provides a prominent sedation effect in colonoscopy. However, anesthesia and sedation induced with propofol in the elderly might result in cardiopulmonary complications, especially when it is combined with opoids in the regimen.
Mengmeng Chen, Yi Lu, Haoran Liu, Qingxia Fu, Jun Li, Junzheng Wu, Wangning Shangguan   +6 more
doaj   +1 more source

Effect of esketamine vs dexmedetomidine adjunct to propofol sedation for pediatric 3Tesla magnetic resonance imaging: a randomized, double-blind, controlled trial

European Journal of Medical Research, 2022
Background Adequate sedation is essential for pediatric patients undergoing 3Tesla (T) magnetic resonance imaging (MRI). Using propofol alone is associated with patient arousing and adverse airway events.
Shang-xian Xu, Xi-sheng Shan, Jin-meng Gao, Hua-xian Liu, Wei-rong Chen, Shan-shan Gao, Fu-hai Ji, Ke Peng, Qian Wang   +8 more
doaj   +1 more source

The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial

Frontiers in Medicine, 2023
ObjectivePropofol-opioids are the most common drug combination and can reduce the dose of propofol and the incidence of adverse events in painless artificial abortion.
Yuling Zheng, Jinping Huang, Ying Mai, Xiaoling Li, Zhongqi Zhang   +4 more
doaj   +1 more source

Comparison of Propofol Alone and Propofol-Ketamine Mixture for Sedation during Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomised Study [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Propofol is frequently used for deep sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP). Sedation-Related Adverse Events (SRAEs), associated with propofol administration, include hypotension, arrhythmia, oxygen desaturation,
Aditya Garg, Mukesh Kumar Prasad, Gurdeep Singh Jheetay, Rohit Kumar Varshney, Amit Kumar Choudhary, Himani Saroha Garg   +5 more
doaj   +1 more source

Propofol Inhibits Androgen Production in Rat Immature Leydig Cells

Frontiers in Pharmacology, 2019
Background: Propofol is a widely used anesthetic. Whether propofol inhibits androgen production by rat Leydig cells and the underlying mechanism remains unclear.
Yiyan Wang, Fei Ge, Xiaoheng Li, Chaobo Ni, Keyang Wu, Wenwen Zheng, Yong Chen, Qingquan Lian, Ren-Shan Ge   +8 more
doaj   +1 more source