Results 1 to 10 of about 129,515 (206)

Pain on injection of propofol. A comparison of cold propofol with propofol premixed with lignocaine [PDF]

Anaesthesia, 1998
Propofol is frequently associated with pain on injection. Previous studies have suggested that chilling of the propofol decreases pain significantly. This prospective, randomised, double‐blind trial was designed to assess the effectiveness of cold propofol compared with propofol premixed with lignocaine in minimising pain on ...
A K, Parmar, C K, Koay
exaly   +3 more sources

Propofol infusion syndrome: a structured literature review and analysis of published case reports

British Journal of Anaesthesia, 2019
Summary: Propofol infusion syndrome is a rare, potentially fatal condition first described in children in the 1990s and later reported in adults. We provide a narrative review of what is currently known about propofol infusion syndrome, including a ...
Mark Bellamy, Luke Mcmenamin
exaly   +2 more sources

Propofol [PDF]

Journal of Pain and Symptom Management, 2010
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. The content is also available on www.palliativedrugs.com and will feature in future editions of the Hospice and Palliative Care Formulary USA and its British and Canadian counterparts. The series editors welcome
Staffan, Lundström, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
  +6 more sources

Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial.

British Journal of Anaesthesia, 2023
BACKGROUND Delirium is a common and disturbing postoperative complication that might be ameliorated by propofol-based anaesthesia. We therefore tested the primary hypothesis that there is less delirium after propofol-based than after sevoflurane-based ...
Shuang-Jie Cao, Yue Zhang, Yu-Xiu Zhang, Wei Zhao, L. Pan, Xu-De Sun, Zhen Jia, W. Ouyang, Qingxiu Ye, Fang Zhang, Yongjuan Guo, Yan-Qiu Ai, Bin-Jiang Zhao, Jianming Yu, Zhi-Heng Liu, Ning Yin, Xueying Li, Jiayue Ma, Hui-juan Li, Mei-Rong Wang, Daniel I. Sessler, D. Ma, Dong-Xin Wang   +22 more
semanticscholar   +1 more source

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Propofol and survival: an updated meta-analysis of randomized clinical trials

Critical Care, 2023
Background Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties.
Y. Kotani, Alessandro Pruna, S. Turi, G. Borghi, Todd C Lee, A. Zangrillo, G. Landoni, L. Pasin   +7 more
semanticscholar   +1 more source

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clinical trial

Basic & Clinical Pharmacology & Toxicology, 2022
Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi‐centre, non‐inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non‐inferiority margin of 8% in patients undergoing ...
Junxiang Li, Xiao Wang, Jin Liu, Xia Wang, Xiangkui Li, Yaping Wang, W. Ouyang, Jun Yu Li, S. Yao, Zhaoqiong Zhu, Qulian Guo, Yonghao Yu, Jin-hai Meng, Y. Zuo   +13 more
semanticscholar   +1 more source

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

New England Journal of Medicine, 2021
BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation.
Christopher G Hughes, P. Mailloux, J. Devlin, J. Swan, R. Sanders, A. Anzueto, J. Jackson, Aimee Hoskins, B. Pun, O. Orun, R. Raman, Joanna L. Stollings, A. Kiehl, M. Duprey, Lan N Bui, H. O'Neal, Allison Snyder, M. Gropper, K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, N. Brummel, T. Girard, R. Dittus, G. Bernard, E. W. Ely, P. Pandharipande   +26 more
semanticscholar   +1 more source

Remimazolam tosilate compared with propofol for gastrointestinal endoscopy in elderly patients: a prospective, randomized and controlled study

BMC Anesthesiology, 2022
Background Remimazolam tosilate (HR7056, RT), a novel ultrashort-acting benzodiazepine, can be used for procedural sedation and general anaesthesia.
Jian-guo Guo, Yitao Qian, Xiaojin Zhang, Shu Han, Qinye Shi, Jianhong Xu   +5 more
semanticscholar   +1 more source

Comparison of remimazolam-based and propofol-based total intravenous anesthesia on postoperative quality of recovery: A randomized non-inferiority trial.

Journal of clinical anesthesia, 2022
STUDY OBJECTIVE The quality of recovery (QoR) of remimazolam-based and propofol-based total intravenous anesthesia was compared as measured by QoR-15 scores. DESIGN A prospective, double-blind, randomized controlled, non-inferiority trial. SETTING An
Jeong Yeon Choi, Hyeyoung Lee, J. Kim, D. W. Han, Ju Yeon Yang, Min Jae Kim, Young Song   +6 more
semanticscholar   +1 more source