Results 1 to 10 of about 133,300 (290)

Pharmacokinetic models for propofol—defining and illuminating the devil in the detail [PDF]

British Journal of Anaesthesia, 2009
The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting. With effect-site targeting the goal is to achieve a user-defined target effect-site
Absalom, A.R., De Smet, Tom, Mani, V., Struys, Michel   +3 more
exaly   +13 more sources

Skin delivery and anti-inflammatory effects of the anesthetic propofol against psoriasiform lesions through KEAP1/Nrf2/HO-1 pathway activation [PDF]

Cellular and Molecular Life Sciences
Propofol is a commonly used anesthetic for sedation during surgery. This drug is reported to exhibit nonanaesthetic immunomodulatory and anti-inflammatory effects. Herein, we investigated the impact of topical propofol delivery with the aim of mitigating
Huang-Ping Yu, Shih-Chun Yang, Cheng-Yu Lin, Ahmed Alalaiwe, Hsiao-Yuan Yang, Jia-You Fang   +5 more
doaj   +2 more sources

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption [PDF]

Communications Biology
Propofol addiction represents a significant clinical challenge with no approved pharmacotherapy. While cognitive decline is a hallmark of substance use disorders, its underlying mechanisms in propofol addiction remain unclear.
Xidi Wang, Shounuo Lin, Zhiting Zou, Dan Zhu, Jiahui Zhou, Xiaoyu Zhang, Jianan Lv, Wenhua Zhou, Yu Liu, Zizhen Si   +9 more
doaj   +2 more sources

Propofol [PDF]

Journal of Pain and Symptom Management, 2010
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. The content is also available on www.palliativedrugs.com and will feature in future editions of the Hospice and Palliative Care Formulary USA and its British and Canadian counterparts. The series editors welcome
Staffan, Lundström, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
  +6 more sources

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Use of remifentanil to reduce propofol injection pain and the required propofol dose in upper digestive tract endoscopy diagnostic tests [PDF]

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The introduction of propofol (2,6-diisopropylphenol) as a sedative agent has transformed the area of sedation for endoscopic procedures.
Gustavo Nadal Uliana, Elizabeth Milla Tambara, Giorgio Alfredo Pedroso Baretta   +2 more
doaj   +6 more sources

The propofol-sparing effect of intravenous lidocaine in elderly patients undergoing colonoscopy: a randomized, double-blinded, controlled study

BMC Anesthesiology, 2020
Background Propofol provides a prominent sedation effect in colonoscopy. However, anesthesia and sedation induced with propofol in the elderly might result in cardiopulmonary complications, especially when it is combined with opoids in the regimen.
Mengmeng Chen, Yi Lu, Haoran Liu, Qingxia Fu, Jun Li, Junzheng Wu, Wangning Shangguan   +6 more
doaj   +1 more source

Esketamine improves propofol-induced brain injury and cognitive impairment in rats

Translational Neuroscience, 2022
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of
Xu Guiping, Wang Yang, Chen Zhe, Zhang Yuxuan, Zhang Xuexue, Zhang Guichao   +5 more
doaj   +1 more source

Comparison of Fentanyl-Propofol and Ketamine-Propofol Combination in Induction and Maintenance with Intravenous Anesthesia for Short Surgical Procedures at Moderate Elevations

Journal of Nepal Health Research Council, 2021
Background: The aim of the study is to evaluate the efficacy of Ketamine-Propofol compared to Fentanyl-Propofol combination during induction and maintenance of total intravenous anesthesia for short surgical procedures at moderate elevation. Methods: A
Ramesh Bhattarai, Pawan Kumar Hamal
doaj   +1 more source

Comparison of Propofol Alone and Propofol-Ketamine Mixture for Sedation during Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomised Study [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Propofol is frequently used for deep sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP). Sedation-Related Adverse Events (SRAEs), associated with propofol administration, include hypotension, arrhythmia, oxygen desaturation,
Aditya Garg, Mukesh Kumar Prasad, Gurdeep Singh Jheetay, Rohit Kumar Varshney, Amit Kumar Choudhary, Himani Saroha Garg   +5 more
doaj   +1 more source