Results 1 to 10 of about 152,792 (340)

Clinical Pharmacokinetics and Pharmacodynamics of Propofol

Clinical Pharmacokinetics, 2018
Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at the GABAA receptor, and ...
Marko M Sahinovic, Michel M R F Struys, Anthony R Absalom   +2 more
exaly   +2 more sources

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Cell Death and Disease, 2019
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system.
Lingbin Sun, Zhengyuan Xia, Zhongjun Zhang   +2 more
exaly   +2 more sources

Skin delivery and anti-inflammatory effects of the anesthetic propofol against psoriasiform lesions through KEAP1/Nrf2/HO-1 pathway activation [PDF]

Cellular and Molecular Life Sciences
Propofol is a commonly used anesthetic for sedation during surgery. This drug is reported to exhibit nonanaesthetic immunomodulatory and anti-inflammatory effects. Herein, we investigated the impact of topical propofol delivery with the aim of mitigating
Huang-Ping Yu, Shih-Chun Yang, Cheng-Yu Lin, Ahmed Alalaiwe, Hsiao-Yuan Yang, Jia-You Fang   +5 more
doaj   +2 more sources

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption [PDF]

Communications Biology
Propofol addiction represents a significant clinical challenge with no approved pharmacotherapy. While cognitive decline is a hallmark of substance use disorders, its underlying mechanisms in propofol addiction remain unclear.
Xidi Wang, Shounuo Lin, Zhiting Zou, Dan Zhu, Jiahui Zhou, Xiaoyu Zhang, Jianan Lv, Wenhua Zhou, Yu Liu, Zizhen Si   +9 more
doaj   +2 more sources

Development of Propofol-Encapsulated Liposomes and the Effect of Intranasal Administration on Bioavailability in Rabbits [PDF]

Pharmaceutics
Background/Objectives: Propofol is frequently used as an intravenous anesthetic and is rapidly metabolized. Therefore, if it could be administered non-invasively (e.g., orally) as premedication, it might hasten emergence from anesthesia, thereby ...
Hitomi Ujita, Hitoshi Higuchi, Yukiko Nishioka, Saki Miyake, Riko Sato, Takuya Miyawaki   +5 more
doaj   +2 more sources

Propofol [PDF]

Journal of Pain and Symptom Management, 2010
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. The content is also available on www.palliativedrugs.com and will feature in future editions of the Hospice and Palliative Care Formulary USA and its British and Canadian counterparts. The series editors welcome
Staffan, Lundström, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
  +6 more sources

Propofol and survival: an updated meta-analysis of randomized clinical trials

Critical Care, 2023
Background Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties.
Y. Kotani, Alessandro Pruna, S. Turi, G. Borghi, Todd C Lee, A. Zangrillo, G. Landoni, L. Pasin   +7 more
semanticscholar   +1 more source

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

New England Journal of Medicine, 2021
BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation.
C. Hughes, P. Mailloux, J. Devlin, J. Swan, R. Sanders, A. Anzueto, J. Jackson, Aimee Hoskins, B. Pun, O. Orun, R. Raman, Joanna L. Stollings, A. Kiehl, M. Duprey, Lan N Bui, H. O'Neal, Allison Snyder, M. Gropper, K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, N. Brummel, T. Girard, R. Dittus, G. Bernard, E. W. Ely, P. Pandharipande   +26 more
semanticscholar   +1 more source

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clinical trial

Basic & Clinical Pharmacology & Toxicology, 2022
Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi‐centre, non‐inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non‐inferiority margin of 8% in patients undergoing ...
Junxiang Li, Xiao Wang, Jin Liu, Xia Wang, Xiangkui Li, Yaping Wang, W. Ouyang, Jun Yu Li, S. Yao, Zhaoqiong Zhu, Qulian Guo, Yonghao Yu, Jin-hai Meng, Y. Zuo   +13 more
semanticscholar   +1 more source