Results 1 to 10 of about 69,815 (159)

A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects

Frontiers in Molecular Neuroscience
Propofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li, Xinqing Yang, Chen Chen, Ziqing Yu, Houping Wang, Ruixue Liu, Jianrong He, Bin Shu, Guangyou Duan, Erquan Zhang, Dapeng Ju, He Huang   +11 more
doaj   +1 more source

Propofol induced diverse and subtype-specific translocation of PKC families

Journal of Pharmacological Sciences, 2018
Propofol is the most commonly used anesthetic. Immunohistochemical studies have reported that propofol translocated protein kinase Cs (PKCs) in cardiomyocyte in a subtype-specific manner; however detailed features of the propofol-induced translocation of
Takeshi Miyahara, Naoko Adachi, Takahiro Seki, Izumi Hide, Shigeru Tanaka, Naoaki Saito, Masahiro Irifune, Norio Sakai   +7 more
doaj   +1 more source

Remifentanil–ketamine vs. propofol–ketamine for sedation in pediatric patients undergoing colonoscopy: A randomized clinical trial

Brazilian Journal of Anesthesiology, 2018
Background and objectives: Pediatric patients frequently require deep sedation or general anesthesia for colonoscopy. This study was designed to compare the sedative efficacy of remifentanil–ketamine combination with propofol–ketamine combination in ...
Feride Karacaer, Ebru Biricik, Murat Ilgınel, Çağatay Küçükbingöz, Mehmet Ağın, Gökhan Tümgör, Yasemin Güneş, Dilek Özcengiz   +7 more
doaj   +1 more source

External validation of the modified Marsh and Schnider models for medium-chain triglyceride propofol in target-controlled infusion anesthesia

BMC Anesthesiology
Background Propofol formulated with medium- and long-chain triglycerides (MCT/LCT propofol) has rapidly replaced propofol formulated with long-chain triglycerides (LCT propofol).
Seongheon Lee, Dongho Kang, Eunjin Song, Sungah Yoo, Seongwook Jeong   +4 more
doaj   +1 more source

Propofol differentially inhibits the release of glutamate, γ-aminobutyric acid and glycine in the spinal dorsal horn of rats [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is
Jing Yang, Wei Wang, Zheng Yong, Weidong Mi, Hong Zhang   +4 more
doaj  

Porous Baicalin-Fe(III) ICP@Propofol nanocomposites for enhanced anesthetic efficacy and reduced toxicity via neuroprotection and ultrasound assistance

Asian Journal of Pharmaceutical Sciences
To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via ...
Shuo Zhang, Lei Shi, Jiansheng He, Ji Xia, Shunlian Li, Rong Wang, Qingyan Ma, Mingting Zhu, Peng Tang, Hao Tian, Feiqian Wang, Mingxi Wan, Daocheng Wu, Wei Gao, Xiancang Ma, Feng Zhu   +15 more
doaj   +1 more source

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption

Communications Biology
Propofol addiction represents a significant clinical challenge with no approved pharmacotherapy. While cognitive decline is a hallmark of substance use disorders, its underlying mechanisms in propofol addiction remain unclear.
Xidi Wang, Shounuo Lin, Zhiting Zou, Dan Zhu, Jiahui Zhou, Xiaoyu Zhang, Jianan Lv, Wenhua Zhou, Yu Liu, Zizhen Si   +9 more
doaj   +1 more source

Comparative Evaluation of Standard Propofol Induction with Propofol Priming and Midazolam-Propofol Co- Induction in Patients Undergoing General Anesthesia

JK Science
Background: Propofol has emerged as an induction agent of choice over the past two decades due to its quick, smooth induction and rapid recovery. The main concern for an anaesthesiologist is the hemodynamic instability caused by the standard induction ...
Hina Kouser, Naine Bhadrala, Anju Jamwal, Urfi Umbreen   +3 more
doaj  

Propofol (Diprivan®) [PDF]

Neurosurgery, 1995
openaire   +2 more sources

Propofol [PDF]

Reactions Weekly, 2021
openaire   +1 more source