Results 41 to 50 of about 69,815 (159)

The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

Frontiers in Pharmacology, 2022
It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia.
Hua Yang, Hui-Min Deng, Hai-Yan Chen, Shu-Heng Tang, Fang Deng, Yu-Gang Lu, Jin-Chao Song   +6 more
doaj   +1 more source

Propofol suppresses migration and vascular mimicry of breast cancer MCF-7 cells by down regulating interleukin-6

Pakistan Journal of Pharmaceutical Sciences
Propofol is widely used in anesthesia, but its role in breast cancer progression remains controversial. This study investigated the molecular mechanisms of propofol in breast cancer, focusing on IL-6 and tumor microenvironment modulation.
Shi-Yi Tian, Ming-Qing Peng, Min Li
doaj   +1 more source

Propofol inhibits proliferation and epithelial-mesenchymal transition of MCF-7 cells by suppressing miR-21 expression

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Breast cancer is a common malignant tumor with a high incidence of recurrence and metastasis. It has been reported that propofol has certain anti-breast cancer effects, but the intrinsic molecular mechanism remains unclear.
Qing Du, Xuezhi Zhang, Xin Zhang, Ming Wei, Hongmei Xu, Shilei Wang   +5 more
doaj   +1 more source

The effects of repeated propofol anesthesia on spatial memory and long-term potentiation in infant rats under hypoxic conditions

Genes and Diseases, 2020
Propofol is widely used as an intravenous drug for induction and maintenance in general anesthesia. Hypoxemia is a common complication during perianesthesia.
Mang Sun, Ruixue Yuan, Hui Liu, Jing Zhang, Shengfen Tu   +4 more
doaj   +1 more source

The Growth of Microorganisms in Propofol and Mixtures of Propofol and Lidocaine

Survey of Anesthesiology, 1999
Propofol emulsion supports bacterial growth. Extrinsic contamination of propofol has been implicated as an etiological event in postsurgical infections. When added to propofol, local anesthetics (e.g., lidocaine) alleviate the pain associated with injecting it. Because local anesthetics have antimicrobial activity, we determined whether lidocaine would
I, Wachowski, D T, Jolly, J, Hrazdil, J C, Galbraith, M, Greacen, A S, Clanachan   +5 more
openaire   +3 more sources

Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report

SAGE Open Medical Case Reports
Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic ...
Haibo Zhang, Yezu Liu, Minlong Liu, Bing Li, Haima Li   +4 more
doaj   +1 more source

Development of Propofol-Encapsulated Liposomes and the Effect of Intranasal Administration on Bioavailability in Rabbits

Pharmaceutics
Background/Objectives: Propofol is frequently used as an intravenous anesthetic and is rapidly metabolized. Therefore, if it could be administered non-invasively (e.g., orally) as premedication, it might hasten emergence from anesthesia, thereby ...
Hitomi Ujita, Hitoshi Higuchi, Yukiko Nishioka, Saki Miyake, Riko Sato, Takuya Miyawaki   +5 more
doaj   +1 more source

The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aminolah Vasigh, Fatemeh Najafi, Molouk Jaafarpour, Javaher Khajavikhan, Ali Khani   +4 more
doaj   +1 more source

Sedation-Analgesia in Elective Colonoscopy: Propofol-Fentanyl Versus Propofol-Alfentanil

Brazilian Journal of Anesthesiology, 2013
Background and objectives: Sedation-analgesia is recommended for comfortable colonoscopy procedures, which are invasive and can be painful. This study aimed to compare the combinations of propofol-alfentanil and propofol-fentanyl for sedation-analgesia ...
Hacer Şebnem Türk, Meltem Aydoğmuş, Oya Ünsal, Hakan Mustafa Köksal, Mehmet Eren Açik, Sibel Oba   +5 more
doaj   +1 more source

Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Choriocarcinoma is a rare gestational trophoblastic tumour. Propofol is one of the commonly used intravenous anaesthetic agents and exerts an anti-tumour role in multiple cancers.
Hai Sun, Yingjian Wang, Wenyu Zhang
doaj   +1 more source