Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia [PDF]
, 2001 Direct current auditory evoked potentials (DC-AEPs) are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in humans. To assess the potential usefulness of DC-AEPs as an indicator of anesthesia in humans,
Bauer, Herbert +5 more
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Central depressant effects and toxicity of propofol in chicks
Toxicology Reports, 2014 Propofol is an ultra-short acting anesthetic agent. The information on the pharmacological and toxicological effects of propofol in the chicken is rather limited.
A.S. Naser, F.K. Mohammad
doaj +1 more source
Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]
, 2009 Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi +5 more
core +2 more sources
Proteomes, 2022 Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation.
Timo Längrich +6 more
doaj +1 more source
Propofol induces nuclear localization of Nrf2 under conditions of oxidative stress in cardiac H9c2 cells. [PDF]
PLoS ONE, 2018 Oxidative stress contributes to myocardial ischemia-reperfusion injury, which causes cardiomyocyte death and precipitate life-threatening heart failure. Propofol has been proposed to protect cells or tissues against oxidative stress.
Takeaki Shinjo +10 more
doaj +1 more source
On the role of the corpus callosum in interhemispheric functional connectivity in humans [PDF]
, 2017 Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal)
Hacker, Carl D. +8 more
core +2 more sources
Cerebral and cardiovascular effects of analgesic doses of ketamine during a target controlled general anesthesia: a prospective randomized study [PDF]
, 2017 Introduction: Ketamine is increasingly being used in various pain settings. The purpose of this study was to assess the effect of an analgesic dose of ketamine in the bispectral index (BIS), spectral edge frequency (SEF-95), density spectral array (DSA),
Araujo, A. M. +3 more
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Inhalational or total intravenous anaesthesia: is total intravenous anaesthesia useful and are there economic benefits? [PDF]
, 2011 PURPOSE OF REVIEW: The comparison of inhalational and intravenous anaesthesia has been the subject of many controlled trials and meta-analyses. These reported diverse endpoints typically including measures of the speed and quality of induction of ...
Holmes, KA, Sneyd, JR
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Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME).
Cristian Durço Paço +8 more
doaj
Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation [PDF]
, 2018 Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of its mechanism of action remains incomplete.
Carnevale, Vincenzo +4 more
core +1 more source