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A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial. [PDF]

Front Med (Lausanne)
Liu J, Zhang W, Li X, Jia D, Bai Z, Chen X.   +5 more
europepmc   +1 more source

Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders. [PDF]

CNS Neurosci Ther
Qin X, Chen X, Yao L, Wang B, Niu H, Liang Z, Zhao Z, Wang J, Huang J, Guo X, Li X.   +10 more
europepmc   +1 more source

The delirium dichotomy of remimazolam: a differential risk profile for emergence delirium versus postoperative delirium in surgical patients: a systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Zhu Z, Wang S, Gu X, Kong J, Zhang Y, Yang L, Ding X, Yu W.   +7 more
europepmc   +1 more source

Sedation Strategies, Drugs, and Protocols Used in Catheter Ablation of Atrial Fibrillation: A Focused Review. [PDF]

Rev Cardiovasc Med
Catuzzo B, Meynet I, Denti S, Amellone C, Coppola G, De Bonis S, Nesti M, Pellegrino PL, Rossillo A, Ziacchi M, Boriani G, D'Onofrio A, Priori SG, Themistoclakis S, Anselmino M, De Ponti R, Italian Association of Arrhythmology and Cardiac Pacing (AIAC).   +16 more
europepmc   +1 more source

Comparison of the recovery profiles of remimazolam-remifentanil and propofol-remifentanil in older patients undergoing laparoscopic abdominal surgeries. [PDF]

Anesth Pain Med (Seoul)
Lee SC, Chung CJ, Ma SH, Choi SR, Park SY, Lee TY.   +5 more
europepmc   +1 more source