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Reactions Weekly, 2008
The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset and offset of drug effect and fast elimination from the body. Elderly patients show a greater sensitivity to the hypnotic effect of propofol. The drug is extensively metabolized in the liver through the cytochrome P450 system and glucuronidation, with potential ...
Vanlersberghe, C., Camu, Fréderic
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The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset and offset of drug effect and fast elimination from the body. Elderly patients show a greater sensitivity to the hypnotic effect of propofol. The drug is extensively metabolized in the liver through the cytochrome P450 system and glucuronidation, with potential ...
Vanlersberghe, C., Camu, Fréderic
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Der Anaesthesist, 2004
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J, Motsch, J, Roggenbach
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Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J, Motsch, J, Roggenbach
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Techniques in Gastrointestinal Endoscopy, 2009
Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Dimensions of Critical Care Nursing, 1997
Critical care nurses frequently care for patients receiving propofol infusions for sedation and control of stress responses. A previous article described the pharmacodynamics of propofol; this article focuses on interventions to improve outcomes in these patients.
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Critical care nurses frequently care for patients receiving propofol infusions for sedation and control of stress responses. A previous article described the pharmacodynamics of propofol; this article focuses on interventions to improve outcomes in these patients.
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International Anesthesiology Clinics, 2011
Ethan O, Bryson, Elizabeth A M, Frost
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Ethan O, Bryson, Elizabeth A M, Frost
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Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis
New England Journal of Medicine, 2021Christopher Hughes +2 more
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