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Der Anaesthesist, 2004
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J, Motsch, J, Roggenbach
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Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J, Motsch, J, Roggenbach
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Propofol Is a Peroxynitrite Scavenger
Anesthesia & Analgesia, 1997P eroxynitrite is a potent oxidant formed by the rapid reaction between nitric oxide and superoxide radical (1). The peroxynitrite anion is relatively stable, but it can rapidly protonate to peroxynitrous acid, an unstable species, which decomposes with a half-life of about one second at pH 7.4 (1,2).
Demiryurek, AT, Kahraman, S
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Clinical Therapeutics, 2019
PURPOSE To investigate the optimal agent combined with propofol for sedation in elderly patients undergoing gastrointestinal endoscopy. METHODS A total of 120 elderly patients scheduled for gastrointestinal endoscopy under propofol-based sedation were ...
Shuang Yin +6 more
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PURPOSE To investigate the optimal agent combined with propofol for sedation in elderly patients undergoing gastrointestinal endoscopy. METHODS A total of 120 elderly patients scheduled for gastrointestinal endoscopy under propofol-based sedation were ...
Shuang Yin +6 more
semanticscholar +1 more source
Techniques in Gastrointestinal Endoscopy, 2009
Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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European Review for Medical and Pharmacological Sciences, 2022
X. Wang +19 more
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X. Wang +19 more
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Dimensions of Critical Care Nursing, 1997
Critical care nurses frequently care for patients receiving propofol infusions for sedation and control of stress responses. A previous article described the pharmacodynamics of propofol; this article focuses on interventions to improve outcomes in these patients.
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Critical care nurses frequently care for patients receiving propofol infusions for sedation and control of stress responses. A previous article described the pharmacodynamics of propofol; this article focuses on interventions to improve outcomes in these patients.
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Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter
Neuron, 2023Ji Hu, Xiao-Na Zhu
exaly