Results 121 to 130 of about 15,550,459 (307)

Determinants of under-five mortality in Zimbabwe: Evidence from the 2015–2016 Zimbabwe demographic Health Survey data

Women and Children Nursing
Background: Child mortality is an important measure of a population’s health status. It is included in the third sustainable development goal that aims to improve global health by reducing under-five mortality to at least as low as 25 per 1000 live ...
Elliot Mbunge, Garikayi Chemhaka, Tafadzwa Dzinamarira, Enos Moyo, Stephen Fashoto, Benhildah Muchemwa, Jolly Buwerimwe, Ester Petrus   +7 more
doaj   +1 more source

Fitting the Cox proportional hazards model to big data

Biometrics
AbstractThe semiparametric Cox proportional hazards model, together with the partial likelihood principle, has been widely used to study the effects of potentially time-dependent covariates on a possibly censored event time. We propose a computationally efficient method for fitting the Cox model to big data involving millions of study subjects ...
Jianqiao Wang, Donglin Zeng, Dan-Yu Lin
openaire   +2 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Limitations of Cox Proportional Hazards Analysis in Mortality Prediction of Patients with Acute Coronary Syndrome

Studies in Logic, Grammar and Rhetoric, 2015
The aim of this study was to evaluate the possibility of incorrect assessment of mortality risk factors in a group of patients affected by acute coronary syndrome, due to the lack of hazard proportionality in the Cox regression model.
Babińska Magdalena, Chudek Jerzy, Chełmecka Elżbieta, Janik Małgorzata, Klimek Katarzyna, Owczarek Aleksander   +5 more
doaj   +1 more source

Multivariate Cox proportional hazard model for assessing outcome-related factors.

, 2016
Multivariate Cox proportional hazard model for assessing outcome-related factors.
Ke-xin Meng (3307953), Hai-long Chen (3307944), Hai-fei He (3307950), Wei Tian (291921), Mei-qi Zhou (3307947)   +4 more
core   +1 more source

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Determinants of mortality using Cox proportional hazard model (N = 147).

, 2019
Determinants of mortality using Cox proportional hazard model (N = 147).
Ibrahim Aliyu (7887044), Ahmad T. Habibu (7887041), Tijjani Hussaini (7887047), AbdulRasheed Yusuf (7887050), Mamman Bajehson (7887026), Mustapha Gidado (7887032), Yakubu Gida (7887053), Baba Maiyaki Musa (7887029), Bassey Nsa (7887035), Useni Sani (7887038)   +9 more
core   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source