Genetic Code Expanded T Cell for Controllable Immunotherapy
Advanced Science, EarlyView.Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang +4 more
wiley +1 more source
Comment on "Prognostic Value of Modified Glasgow Prognostic Score in Acute Decompensated Heart Failure with Reduced Ejection Fraction". [PDF]
J Clin Pract ResWang Z, Shao L.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo +11 more
wiley +1 more source
Association of Systolic and Diastolic Blood Pressure with the Risk of End-Stage Renal Disease in Older Type 2 Diabetes Mellitus Patients without Cardiovascular Disease: A Nationwide Population-Based Study (Diabetes Metab J 2025;49:1308-17). [PDF]
Diabetes Metab JHong S +6 more
europepmc +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Association between Clostridioides difficile Test Positivity and Colorectal Cancer Incidence in a Multisite Hospital-Based Retrospective Cohort Analysis. [PDF]
Cancer Res CommunRifkin S +8 more
europepmc +1 more source
Recent Advances and Challenges in Ammonia‐Hydrogen Energy Conversion
Advanced Science, EarlyView.This work summarizes the latest progress of various catalytic methods in ammonia‐hydrogen energy conversion. The challenges and outlook of ammonia‐hydrogen energy conversion system are also emphasized. This work expects to build a blueprint of renewable and efficient ammonia‐hydrogen energy conversion systems under mild conditions.
Menghao Lv +6 more
wiley +1 more source
U-shaped association between neutrophil-percentage-to-albumin ratio and all-cause mortality in adults with hyperlipidemia: A prospective cohort study of NHANES 1999 to 2018. [PDF]
Medicine (Baltimore)Wang J, Yang Y, Jiang K, Chen H, Wang H.
europepmc +1 more source
Assessing Household Welfare in Response to Rising Food Prices in The Gambia
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This study examines how rising food prices affected household welfare in The Gambia using nationally representative data from the 2015/16 Integrated Household Survey (IHS‐3). The analysis reflects household consumption behavior and market conditions prevailing during that period and provides a structural benchmark for understanding ...
Roger Vorsah +3 more
wiley +1 more source