Results 101 to 110 of about 1,821,882 (341)

Univariate Cox proportional hazards analysis.

, 2015
a Hazard ratio adjusted for age and gender. In bold variables with p < 0.2 implemented in the multivariate cox proportional hazards analysis.Univariate Cox proportional hazards analysis.
Manon Barutaut (704548), Celine Caubère (704549), Franck Desmoulin (216110), Gurbuz Murat (704551), Rudolf De Boer (704552), Fatima Smih (216108), Matthieu Berry (216111), François Koukoui (216125), Maria Francesca Evaristi (704550), Michel Galinier (216129), Philippe Rouet (216132)   +10 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A Proportional Hazards Regression Model for the Sub-distribution with Covariates Adjusted Censoring Weight for Competing Risks Data

Scandinavian journal of statistics, theory and applications, 2015
With competing risks data, one often needs to assess the treatment and covariate effects on the cumulative incidence function. Fine and Gray proposed a proportional hazards regression model for the subdistribution of a competing risk with the assumption ...
Peng He, F. Eriksson, Thomas Scheike, Mei‐jie Zhang   +3 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Trend-constrained corrected score for proportional hazards model with covariate measurement error

Contemporary Clinical Trials Communications, 2015
In many medical research studies, survival time is typically the primary outcome of interest. The Cox proportional hazards model is the most popular method to investigate the relationship between covariates and possibly right-censored survival time ...
Ming Zhu, Yijian Huang
doaj   +1 more source

Properties and inference for proportional Hazard models

Revista Colombiana de Estadística, 2013
We consider an arbitrary continuous cumulative distribution function F(x) with a probability density function f(x) = dF(x)/dx and hazard function h f(x)=f(x)/[1-F(x)]. We propose a new family of distributions, the so-called proportional hazard distribution-function, whose hazard function is proportional to h f(x).
MARTÍNEZ-FLÓREZ, GUILLERMO, MORENO-ARENAS, GERMÁN, VERGARA-CARDOZO, SANDRA   +2 more
openaire   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Tree-augmented Cox proportional hazards models

, 2005
We study a hybrid model that combines Cox proportional hazards regression with tree-structured modeling. The main idea is to use step functions, provided by a tree structure, to \u27augment\u27 Cox (1972) proportional hazards models.
Su, XG, Tsai, CL, Tsai, Chih Ling, Su, Xiaogang   +3 more
core   +2 more sources

A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects

Contemporary Clinical Trials Communications, 2015
The semi-parametric proportional hazards model is widely adopted in randomized clinical trials with time-to-event outcomes, and the log-rank test is frequently used to detect a potential treatment effect.
Pei He, Zheng Su
doaj   +1 more source

Analysis of the Proportional Hazards Model with Sparse Longitudinal Covariates

Journal of the American Statistical Association, 2015
Regression analysis of censored failure observations via the proportional hazards model permits time-varying covariates that are observed at death times.
Hongyuan Cao, M. M. Churpek, Donglin Zeng, J. Fine   +3 more
semanticscholar   +1 more source