Results 81 to 90 of about 656,427 (214)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Proportional representation review
, 1914 Includes supplements.Includes supplements.Mode of access: Internet.Organ of the Proportional Representation League (called, 1914-1920, American Proportional Representation League).The Proportional representation review (v. 1-3) was issued in Chicago from
American Proportional Representation League. +1 more
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Tree-augmented Cox proportional hazards models
, 2005 We study a hybrid model that combines Cox proportional hazards regression with tree-structured modeling. The main idea is to use step functions, provided by a tree structure, to \u27augment\u27 Cox (1972) proportional hazards models.
Su, XG +3 more
core +2 more sources
Optimal designs for full and partial likelihood information - with application to survival models [PDF]
, 2015 Time-to-event data are often modelled through Cox's proportional hazards model for which inference is based on the partial likelihood function. We derive a general expression for the asymptotic covariance matrix of Cox's partial likelihood estimator for ...
Konstantinou, Maria +3 more
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Limitations of using COX proportional hazards model in cardiovascular research
Cardiovascular DiabetologyThe article by Zhao et al. titled “Associations of Triglyceride-Glucose (TyG) Index with Chest Pain Incidence and Mortality among the U.S. Population” provides valuable insights into the positive correlation between the TyG index and chest pain incidence,
Nan Jiang, Yongfa Wu, Chengjia Li
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A proportional hazards model of bank failure: an examination of its usefulness as an early warning tool [PDF]
An explanation of how a Cox proportional hazards model can be used to identify both failed and healthy banks with a high degree of accuracy using a relatively small set of publicly available data.Bank ...
Gary Whalen
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Likelihood-Based Estimation of a Proportional-Hazard, Competing- Risk Model with Grouped Duration Data [PDF]
This short paper demonstrates two important results related to the estimation of competing-risk models under the proportional-hazards assumption with grouped duration data.
Mark Yuying An
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