Results 61 to 70 of about 656,427 (214)
Discussing the Strehler-Mildvan model of mortality
Demographic Research, 2012 BACKGROUND Half a century ago Strehler and Mildvan (1960) have published the seminal paper that, based on some assumptions (postulates), theoretically 'justified' the Gompertz law of mortality.
Maxim Finkelstein
doaj
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Efficient Post-Shrinkage Estimation Strategies in High-Dimensional Cox’s Proportional Hazards Models
EntropyRegularization methods such as LASSO, adaptive LASSO, Elastic-Net, and SCAD are widely employed for variable selection in statistical modeling. However, these methods primarily focus on variables with strong effects while often overlooking weaker signals,
Syed Ejaz Ahmed +2 more
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Weighted Cox Regression Using the R Package coxphw
Journal of Statistical Software, 2018 Cox's regression model for the analysis of survival data relies on the proportional hazards assumption. However, this assumption is often violated in practice and as a consequence the average relative risk may be under- or overestimated.
Daniela Dunkler +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Serious Hazards of Transfusion (SHOT) Annual Report 2003 [PDF]
, 2023 SHOT is affiliated to the Royal College of PathologistsWith this 7th annual report, SHOT provides an increasingly authoritative analysis of serious transfusion hazards in the UK and an evidence base for blood safety initiatives, policies and guidelines ...
Serious Hazards of Transfusion (SHOT)
core
Trend-constrained corrected score for proportional hazards model with covariate measurement error
Contemporary Clinical Trials Communications, 2015 In many medical research studies, survival time is typically the primary outcome of interest. The Cox proportional hazards model is the most popular method to investigate the relationship between covariates and possibly right-censored survival time ...
Ming Zhu, Yijian Huang
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