Results 61 to 70 of about 465,241 (284)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro +11 more
wiley +1 more source
Discussing the Strehler-Mildvan model of mortality
Demographic Research, 2012 BACKGROUND Half a century ago Strehler and Mildvan (1960) have published the seminal paper that, based on some assumptions (postulates), theoretically 'justified' the Gompertz law of mortality.
Maxim Finkelstein
doaj
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. [PDF]
, 2014 BackgroundThe age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high ...
Agrawal, Arpana +23 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Data‐driven framework for warranty claims forecasting with an application for automotive components
Engineering ReportsAutomakers spend billions of dollars annually towards warranty costs, and warranty reduction is typically high on their priorities. An accurate understanding of warranty performance plays a critical role in controlling and steering the business, and it ...
Mohammad Babakmehr +6 more
doaj +1 more source
E-Jurnal Matematika, 2013 Survival analysis is a statistical method that accommodates the collection of censored data. One of popular method in survival analysis is the Cox Proportional Hazard Regression.
I GEDE ARI SUDANA +2 more
doaj +1 more source
Proportional Hazards Regression for Cancer Studies [PDF]
Biometrics, 2008 Summary. There has been some recent work in the statistical literature for modeling the relationship between the size of cancers and probability of detecting metastasis, i.e., aggressive disease. Methods for assessing covariate effects in these studies are limited.
openaire +3 more sources
Proportional hazards models with discrete frailty [PDF]
Lifetime Data Analysis, 2010 We extend proportional hazards frailty models for lifetime data to allow a negative binomial, Poisson, Geometric or other discrete distribution of the frailty variable. This might represent, for example, the unknown number of flaws in an item under test.
Caroni, Chrys +2 more
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source