Results 51 to 60 of about 251,158 (254)
Discussing the Strehler-Mildvan model of mortality
BACKGROUND Half a century ago Strehler and Mildvan (1960) have published the seminal paper that, based on some assumptions (postulates), theoretically 'justified' the Gompertz law of mortality.
Maxim Finkelstein
doaj
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger +8 more
wiley +1 more source
Proportional hazards models with discrete frailty [PDF]
We extend proportional hazards frailty models for lifetime data to allow a negative binomial, Poisson, Geometric or other discrete distribution of the frailty variable. This might represent, for example, the unknown number of flaws in an item under test.
Caroni, Chrys +2 more
openaire +4 more sources
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley +1 more source
Survival analysis is a statistical method that accommodates the collection of censored data. One of popular method in survival analysis is the Cox Proportional Hazard Regression.
I GEDE ARI SUDANA +2 more
doaj +1 more source
Properties and inference for proportional Hazard models
We consider an arbitrary continuous cumulative distribution function F(x) with a probability density function f(x) = dF(x)/dx and hazard function h f(x)=f(x)/[1-F(x)]. We propose a new family of distributions, the so-called proportional hazard distribution-function, whose hazard function is proportional to h f(x).
MARTÍNEZ-FLÓREZ, GUILLERMO +2 more
openaire +4 more sources
ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas +7 more
wiley +1 more source
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source

