Results 151 to 160 of about 1,821,882 (341)

Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model.

PLoS ONE
BackgroundIn recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is
Huan Zhang, Shan Zhao, Pengzhong Lv
doaj   +1 more source

Multivariable Cox proportional hazards regression analysis.

, 2016
Multivariable Cox proportional hazards regression analysis.
Hui Xia (133168), Fudong Lv (3179163), Ruidong Zhu (3179169), Fang Cao (236777), Lu Yu (74016), Feng Chen (25347), Jiliang Feng (3179166), Shijie Zhang (119400), Chun Chang (415999), Guohua Zhu (73670), Lin Sun (105539)   +10 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Cox proportional hazards analysis for VAF.

, 2017
Cox proportional hazards analysis for VAF.
Ji-Young Park (194338), So Yon Rhee (3663331), Shin-Wook Kang (277265), Hee Jung Jeon (3663334), Jieun Oh (783748), Dong Ho Shin (299513)   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cox proportional-hazards regression for survival.

, 2019
Cox proportional-hazards regression for survival.
Ana Ángela Romero-Haro (3293235), Carlos Alonso-Alvarez (223153), Alejandro Cantarero (4514167), Olivier Chastel (288198), Lorenzo Pérez-Rodríguez (3247797)   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The two-way proportional hazards model

, 2002
Survival analysis problems often involve dual timescales, most commonly calendar date and lifetime, the latter being the elapsed time since an initiating event such as a heart transplant.
Bradley Efron
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A COMPARISON OF MULTIPLICATIVE AND ADDITIVE HAZARD MODELS USING THE HAZARD AND SURVIVAL RATIO

Media Statistika
The Cox multiplicative hazards regression and Aalen additive hazards regression models are widely used for survival data analysis. While the Cox model emphasizes hazard ratios or relative risks, the Aalen model focuses on relative survival or excess ...
Danardono Danardono, Gunardi Gunardi
doaj   +1 more source