Results 161 to 170 of about 1,821,882 (341)

Multivariate Cox proportional hazards model for women.

, 2015
Multivariate Cox proportional hazards model for women.
Richard Pietras (743627), Lee Goodglick (195369), Steve Horvath (28847), David Chia (233747), Erin L. Maresh (743623), Vei Mah (743620), Mohammad Alavi (743621), Diana C. Márquez-Garbán (743622), Sara R. Kim (743624), Lora Bagryanova (743625), Sara Huerta-Yepez (743626)   +10 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Group sequential design for time-to-event outcome with non-proportional hazards using the concept of relative time utilizing two different Weibull distributions

Contemporary Clinical Trials Communications
A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing in phase III trials. Literature is well developed in the case of continuous and binary outcomes, however, in case of trials with a time ...
Milind A. Phadnis, Nadeesha Thewarapperuma, Matthew S. Mayo   +2 more
doaj   +1 more source

Cox proportional hazards regression analysis for MACCE.

, 2016
Cox proportional hazards regression analysis for MACCE.
Pyung Chun Oh (3152958), Jon Suh (3152940), Dae-Hyeok Kim (3152931), Ho-Jun Jang (3152943), Sung Woo Kwon (3152955), Tae-Hoon Kim (346667), Seong-Il Woo (3152949), Jun Kwan (515266), Hyun Woo Park (599667), Sung-Hee Shin (3152937), Sang-Don Park (3152946), WoongChol Kang (3152952), Jeonggeun Moon (3152934), Young Ju Suh (28950)   +13 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Simple Test for the Absence of Covariate Dependence in Hazard Regression Models

This paper extends commonly used tests for equality of hazard rates in a two-sample or k-sample setup to a situation where the covariate under study is continuous.
Bhattacharjee, Arnab
core  

Proportional hazards analysis of PFS (N = 99).

, 2019
Proportional hazards analysis of PFS (N = 99).
Tristan M. Sissung (220741), Arlene Berman (6410921), Gideon M. Blumenthal (6410918), Arun Rajan (399950), Giuseppe Giaccone (62965), Seth M. Steinberg (202367), David J. Liewehr (202365), William D. Figg (220748)   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Continuity Correction and Standard Error Calculation for Testing in Proportional Hazards Models

Stats
Standard asymptotic inference for proportional hazards models is conventionally performed by calculating a standard error for the estimate and comparing the estimate divided by the standard error to a standard normal distribution.
Daniel Baumgartner, John E. Kolassa
doaj   +1 more source

Multivariate Cox proportional hazards analysis for VAF.

, 2017
Multivariate Cox proportional hazards analysis for VAF.
Ji-Young Park (194338), So Yon Rhee (3663331), Shin-Wook Kang (277265), Hee Jung Jeon (3663334), Jieun Oh (783748), Dong Ho Shin (299513)   +5 more
core   +1 more source