Results 121 to 130 of about 784,391 (328)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Time-to-event analysis

open access: yesPerspectives in Clinical Research
Survival analysis (or time-to-event analysis) deals with data where the outcome of interest is the length of time until the occurrence of an event. This type of analysis is unique because the event may not occur in all participants (known as censoring ...
Priya Ranganathan   +2 more
doaj   +1 more source

The Duration of Trade Revisited: Continuous-Time vs. Discrete-Time Hazards [PDF]

open access: yes
The recent literature on the duration of trade has predominantly analyzed the determinants of trade flow durations using Cox proportional hazards models.
Hess, Wolfgang, Persson, Maria
core  

Retinopathy prediction in type 2 diabetes: Time-varying Cox proportional hazards and machine learning models

open access: gold, 2023
Panu Looareesuwan   +10 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Group sequential design for time-to-event outcome with non-proportional hazards using the concept of relative time utilizing two different Weibull distributions

open access: yesContemporary Clinical Trials Communications
A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing in phase III trials. Literature is well developed in the case of continuous and binary outcomes, however, in case of trials with a time ...
Milind A. Phadnis   +2 more
doaj   +1 more source

Functional ANOVA modeling for proportional hazards regression [PDF]

open access: bronze, 2000
Jianhua Z. Huang   +3 more
openalex   +1 more source

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