Results 71 to 80 of about 349,638 (336)

Analysis of time to event outcomes in randomized controlled trials by generalized additive models. [PDF]

PLoS ONE, 2015
BACKGROUND:Randomized Controlled Trials almost invariably utilize the hazard ratio calculated with a Cox proportional hazard model as a treatment efficacy measure.
Christos Argyropoulos, Mark L Unruh
doaj   +1 more source

Causal Interactions in the Proportional Hazards Model [PDF]

Epidemiology, 2011
The paper relates estimation and testing for additive interaction in proportional hazards models to causal interactions within the counterfactual framework. A definition of a causal interaction for time-to-event outcomes is given that generalizes existing definitions for dichotomous outcomes. Conditions are given concerning the relative excess risk due
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Asymptotic normality of corrected estimator in Cox proportional hazards model with measurement error

Modern Stochastics: Theory and Applications, 2014
Cox proportional hazards model is considered. In Kukush et al. (2011), Journal of Statistical Research, Vol. 45, No. 2, 77–94 simultaneous estimators $\lambda _{n}(\cdot )$ and $\beta _{n}$ of baseline hazard rate $\lambda (\cdot )$ and regression ...
C. Chimisov, A. Kukush
doaj   +1 more source

Survival analysis of irish amyotrophic lateral sclerosis patients diagnosed from 1995-2010. [PDF]

PLoS ONE, 2013
IntroductionThe Irish ALS register is a valuable resource for examining survival factors in Irish ALS patients. Cox regression has become the default tool for survival analysis, but recently new classes of flexible parametric survival analysis tools ...
James Rooney, Susan Byrne, Mark Heverin, Bernie Corr, Marwa Elamin, Anthony Staines, Ben Goldacre, Orla Hardiman   +7 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Geoadditive hazard regression for interval censored survival times [PDF]

, 2005
The Cox proportional hazards model is the most commonly used method when analyzing the impact of covariates on continuous survival times. In its classical form, the Cox model was introduced in the setting of right-censored observations.
Kneib, Thomas
core   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Adjusting for bias introduced by instrumental variable estimation in the Cox Proportional Hazards Model

, 2017
Instrumental variable (IV) methods are widely used for estimating average treatment effects in the presence of unmeasured confounders. However, the capability of existing IV procedures, and most notably the two-stage residual inclusion (2SRI) procedure ...
Goodney, Philip P., MacKenzie, Todd A., Martinez-Camblor, Pablo, O'Malley, A. James, Staiger, Douglas O.   +4 more
core   +1 more source