Results 71 to 80 of about 228,669 (304)
Survival analysis using Cox proportional hazards model. [PDF]
, 2015 β, beta coefficient; SE, standard error; Wald, Wald statistic; df, degree of freedom; Sig., P value.Survival analysis using Cox proportional hazards model.
Bo Jin (169366) +15 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reasons why osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model
RMD Open, 2019 Objectives To identify potentially modifiable factors that mediate the association between symptomatic osteoarthritis (OA) and premature mortality.Methods A population-based prospective cohort study; primary care medical record data were linked to self ...
George Peat +7 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Time and dose dependency of bone-sarcomas in patients injected with radium-224 [PDF]
, 1988 The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear ...
Land, C.E. +8 more
core +1 more source
Asymptotic normality of corrected estimator in Cox proportional hazards model with measurement error
Modern Stochastics: Theory and Applications, 2014 Cox proportional hazards model is considered. In Kukush et al. (2011), Journal of Statistical Research, Vol. 45, No. 2, 77–94 simultaneous estimators $\lambda _{n}(\cdot )$ and $\beta _{n}$ of baseline hazard rate $\lambda (\cdot )$ and regression ...
C. Chimisov, A. Kukush
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Estimation of treatment effects in weighted log-rank tests
Contemporary Clinical Trials Communications, 2017 Non-proportional hazards have been observed in clinical trials. The log-rank test loses power and the standard Cox model generally produces biased estimates under such conditions.
Ray S. Lin, Larry F. León
doaj +1 more source
Optimal designs for full and partial likelihood information - with application to survival models [PDF]
, 2015 Time-to-event data are often modelled through Cox's proportional hazards model for which inference is based on the partial likelihood function. We derive a general expression for the asymptotic covariance matrix of Cox's partial likelihood estimator for ...
Konstantinou, Maria +3 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source