Results 71 to 80 of about 2,254,446 (272)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Types of Pottery from the Novoslavka-2 Burial Ground

open access: yesАрхеология евразийских степей
We present the results of the preliminary study of pottery obtained during 4-year studies at the Novoslavка-2 burial ground. Dated to 450-550 AD based on artifact analysis, this burial ground belongs to the Komintern type of the Imenkovo culture.
Renat R. Valiev, Anna A. Kuklina
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Sample size estimation and power analysis for clinical research studies

open access: yesJournal of Human Reproductive Sciences, 2012
Determining the optimal sample size for a study assures an adequate power to detect statistical significance. Hence, it is a critical step in the design of a planned research protocol.
K P Suresh, S Chandrashekara
doaj   +1 more source

Trade and Expropriation: A Factor Proportions Approach [PDF]

open access: yes
An extended small open economy model is developed and used to examine the effect of trade on the illicit expropriation of incomes and the provision of legal services.
Arghya Ghosh, Peter Robertson
core  

Loss of redundant gene expression after polyploidization in plants

open access: yes, 1978
Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25 ...
C. Aragoncillo   +20 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Recognition of Geometrical and Proportional Principles in Open and Semi-Open Spaces of Hot and Humid Climate (Case Study: Historical Houses of Bushehr) [PDF]

open access: yesتوسعه پایدار شهری
Proportion is one of the significant design principles featured in Iranian architecture. Several factors are influential in applying a certain type of spatial proportions. Climate and ecology are the most important ones.
Neda Naseri   +4 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

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