Results 111 to 120 of about 96,658 (272)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

A case of propylthiouracil induced antineutrophil cytoplasmic antibody associated vasculopathy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Nikhil Dwivedi, Jessica Witherspoon, Sarath Bodapati   +2 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Myocardial toxicity in two dogs with natural exposure to ractopamine

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract Two dogs that lived in a farm setting were presented to the Texas A&M University Veterinary Medical Teaching Hospital's Emergency Service exhibiting muscle tremors and ventricular arrhythmias following ingestion of ractopamine, a ß‐2 agonist feed‐additive used in beef cattle, pigs and turkeys intended for slaughter to increase muscle mass. The
Sophie Tippit, Igor Yankin, Molly Wart, Sonya Wesselowski   +3 more
wiley   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Bilateral Cardiac Sympathetic Denervation in Inherited Cardiac Arrhythmias

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
The figure shows the outcomes and adverse effects experienced by five patients who underwent BCSD for inherited arrhythmias, including CPVT and LQTS. BCSD resulted in significant or partial effects and favorable outcomes. Case 1: In a patient with CPVT, polymorphic ventricular tachycardia was not induced after BCSD.
Hisaaki Aoki, Michiko Minegishi, Katsunori Okajima, Takashi Kumamoto, Daiji Takeuchi   +4 more
wiley   +1 more source

Propranolol for Off-label Treatment of Patients With Melanoma: Results From a Cohort Study

JAMA Oncology, 2017
V. de Giorgi, M. Grazzini, S. Benemei, N. Marchionni, E. Botteri, E. Pennacchioli, P. Geppetti, S. Gandini   +7 more
semanticscholar   +1 more source

The Evolving Role of Ivabradine for Focal Atrial Tachycardia: A Systematic Review

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Overview of the evolving role of ivabradine in focal atrial tachycardia (FAT), highlighting its HCN‐mediated mechanism, features of ivabradine‐sensitive FAT, hypothesized predictors of response, special populations requiring special considerations, and potential adverse effects.
Haikal Balweel, Rifqi Rizkani Eri, Sania Zahrani, Kiara Hanna Quinncilla, Novaro Adeneur Tafriend, Agus Harsoyo   +5 more
wiley   +1 more source