The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. [PDF]
, 2016 Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ...
Benovic, Jeffrey L. +6 more
core +2 more sources
Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke +2 more
wiley +1 more source
Propranolol Reduces Cancer Risk
Medicine, 2015 &bgr;-Blockers have been reported to exhibit potential anticancer effects in cancer cell lines and animal models. However, clinical studies have yielded inconsistent results regarding cancer outcomes and cancer risk when &bgr;-blockers were used.
P. Chang +6 more
semanticscholar +1 more source
Benign Idiopathic Myoclonus: A New Clinical Entity?
Movement Disorders Clinical Practice, EarlyView.Abstract Background Myoclonus is a brief shock‐like, involuntary movement, which can be distinguished in physiologic, essential, epileptic, and symptomatic, according to its etiology. Physiologic myoclonus typically occurs in healthy people without disability or progression.
Giorgia Sciacca +6 more
wiley +1 more source
LC-MS/MS Estimation of Propranolol level in Exhaled Breath Condensate
Pharmaceutical Sciences, 2017 Background: Exhaled breath condensate (EBC) could be used as a non-invasive and alternative specimen to urine and blood for monitoring propranolol levels.
Samin Hamidi 1, Maryam Amini 2, Maryam Khoubnasabjafari 3, Vahid Jouyban-Gharamaleki 4,5, Hossein Sate 6, Abolghasem Jouyban 5,7 *
doaj +1 more source
Reasoning by analogy in the generation of domain acceptable ontology refinements [PDF]
, 2010 Refinements generated for a knowledge base often involve the learning of new knowledge to be added to or replace existing parts of a knowledge base. However, the justifiability of the refinement in the context of the domain (domain acceptability) is ...
L. Moss +5 more
core +1 more source
Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation
Stem Cells Translational Medicine, 2015 Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β‐adrenergic receptor (βAR) antagonist that can lower cAMP
N. Munabi +10 more
semanticscholar +1 more source
Pathophysiological Role of Primary Motor Cortex in Essential Tremor
Movement Disorders, EarlyView.Abstract Background Essential tremor (ET) is one of the most prevalent movement disorders. However, the complete understanding of ET pathophysiology remains elusive. Objective To explore the pathophysiological role of primary motor cortex (M1) in ET, specifically exploring its neurophysiological changes and their correlation with voluntary motor ...
Daniele Birreci +10 more
wiley +1 more source
The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series
Frontiers in Medicine, 2017 IntroductionRecent studies have examined the effectiveness of alpha-2 adrenergic agonists for controlling delirium and agitation. Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood–brain barrier, has not been ...
Junji Shiotsuka +3 more
doaj +1 more source
Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]
, 2004 Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C. +2 more
core +1 more source