Results 111 to 120 of about 19,655 (167)

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2151-2156, September 2026.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +1 more source

Perioperative propranolol during robotic‐assisted radical prostatectomy: A randomised, double‐blind, placebo‐controlled, pilot trial (PeP‐RALP)

BJUI Compass, Volume 7, Issue 9, September 2026.
Abstract Objective This study aimed to determine the feasibility and safety of administering perioperative propranolol, as an adjunct to reduce prostate cancer recurrence, in patients undergoing robotic‐assisted laparoscopic prostatectomy (RALP) for European Association of Urology (EAU) intermediate‐ or high‐risk prostate cancer.
Shivanthe Sivanesan, Håkon Ramberg, Thomas Kristiansen, Suraj B. Thapa, Marthe Bjøre, Viktor Berge, Fredrik Ottosson, Bjørn Brennhovd, Anne M. H. Storås, Per M. Thorsby, Sandra R. Dahl, Alfonso Urbanucci, Helene Hartvedt Grytli, Lars Bjerke, Kristin Austlid Taskén   +14 more
wiley   +1 more source

Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3115-3123, September 2026.
Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong, Jungryul Kim, Woojin Jung, Jiyeon Jeon, Hyeongjun Jo, Kyoung‐Bin Ryu, Ja‐Young Hong, Kwan Soo Kim, Seongjun Yang, Hee Young Ju, Hwi‐yeol Yun, Jung‐woo Chae, Keon Hee Yoo, Soyoung Lee   +13 more
wiley   +1 more source

Once-a-Day Administration of R(+) Propranolol Is Sufficient to Block Vasculogenesis in a Xenograft Model of Infantile Hemangioma

Journal of Vascular Anomalies
Objective:. Infantile hemangioma (IH) is a benign vascular tumor that occurs in 5% of infants, predominantly in female and preterm neonates. Propranolol is the mainstay of treatment for IH.
Annegret Holm, Jerry Wei Heng Tan, Luke Borgelt, John B. Mulliken, Joyce Bischoff   +4 more
doaj   +1 more source

Hidden in Plain Sight: Electromechanical Window Negativity in Congenital Long QT Syndrome

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Risk stratification in congenital long QT syndrome (LQTS) continues to rely heavily on genotype and QTc duration, despite their limited ability to identify individuals at highest arrhythmic risk. The electromechanical window (EMW) is a validated marker of malignant arrhythmia susceptibility, yet its presence within routine echocardiographic ...
Toby Paterson, Roy Sanders, Vivetha Pooranachandran   +2 more
wiley   +1 more source

The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

, 2013
Bojko Bjelakovic,1,2 Mila Bojanovic,2,3 Stevo Lukic,2,4 Ljiljana Saranac,1,2 Vladislav Vukomanovic,5,6 Sergej Prijic,5 Nikola Zivkovic,7 Dusica Randjelovic11Clinic of Pediatrics, Clinical Center, Nis, Serbia; 2Faculty of Medicine, University of Nis, Nis,
Bjelakovic B, Zivkovic N, Bojanovic M, Saranac L, Randjelovic D, Prijic S, Lukic S, Vukomanovic V   +7 more
core  

Propranolol in pregnancy three year prospective study

, 1983
We compared propranolol with methyldopa in a randomized prospective study of 28 women with pregnancy associated hypertension. Both drugs were equally effective in controlling maternal hypertension.
Craswell P.W., Livingstone I., Smith M.T., Bevan E.B., Eadie M.J.   +4 more
core   +1 more source

Propranolol as Salvage Therapy for Refractory Congenital Chylous Ascites in a Preterm Neonate: A Case Report and Review of the Literature

Children
Background/Objectives: Congenital chylous ascites is a rare neonatal condition characterized by the accumulation of lymphatic fluid within the peritoneal cavity.
Nicoletta Menzella, Francesca Riitano, Simonetta Costa, Francesca Paola Fusco, Simona Fattore, Chiara Tirone, Francesca Stollagli, Giovanni Vento   +7 more
doaj   +1 more source

Cannabidiol Ameliorates Blood–Brain Barrier Dysfunction and Inhibits Memory Astrocytes Activation in Mice With Sickness‐Like Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Depressive‐like mice showed blood–brain barrier disruption with loss of endothelial tight junction proteins, astrocytic AQP4 depolarization, and elevated neuroinflammation. A single dose of cannabidiol restored BBB integrity and astrocyte polarity, suppressed memory astrocyte–mediated secondary neuroinflammation, and alleviated depressive‐like ...
Yue Chen, Hui Ma, Qian Long, Xuan Fang, Xiaotong Li, Wenhui Xiao, Xinzhou Deng, Fuze Du, Yifei Tan, Yan Wang, Xiaoxia Jiang, Bo Gao, Xin Qiao   +12 more
wiley   +1 more source