Results 11 to 20 of about 104,112 (336)

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Scientific Reports, 2022
Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries.
Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona   +7 more
doaj   +1 more source

The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens

Biomedicines, 2023
The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems play important roles in controlling bacterial virulence, and their targeting ...
Hadil Faris Alotaibi, Haifa Alotaibi, Khaled M. Darwish, El-Sayed Khafagy, Amr S. Abu Lila, Mohamed A. M. Ali, Wael A. H. Hegazy, Samar Zuhair Alshawwa   +7 more
doaj   +1 more source

Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis [PDF]

, 2017
Background The objective of this systematic review was to determine the effectiveness and safety of propranolol compared to placebo or usual care for improving clinical relevant outcomes in severely burned patients (TBSA \u3e20%).
Ferrada, Paula, Foianini, Jorge Esteban, García-Perdomo, Herney Andrés, Gomez, Diego Andrés, Manzano-Nunez, Ramiro, Ordoñez Delgado, Carlos Alberto   +5 more
core   +3 more sources

Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength [PDF]

, 2014
Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone
Apel, Arai, Aro, Aspenberg, Baek, Bliziotes, Bonnet, Bonnet, Bostrom, Chenu, Cherruau, Chhabra, Ding, Elefteriou, Elefteriou, Graham, Hara-Irie, Harrison, He, Hohmann, Jeyabalan, Kajimura, Kondo, Long, Mach, Madsen, Marenzana, Marsell, Minkowitz, Moran, Morgan, Pierroz, Pullar, Reid, Rodrigues, Serre, Strömberg, Takeda, Takeda, Togari   +39 more
core   +2 more sources

Facile Synthesis of Propranolol and Novel Derivatives

Journal of Chemistry, 2020
Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives.
Vy Anh Tran, Nguyen Hai Tai Tran, Long Giang Bach, Trinh Duy Nguyen, Thi Thuong Nguyen, Tan Tai Nguyen, Thi Anh Nga Nguyen, The Ky Vo, Thu-Thao Thi Vo, Van Thuan Le   +9 more
doaj   +1 more source

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Frontiers in Oncology, 2021
Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance.
Jhuma Saha, Jong Hyuk Kim, Jong Hyuk Kim, Jong Hyuk Kim, Clarissa N. Amaya, Clarissa N. Amaya, Caleb Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Brad A. Bryan, Erin B. Dickerson, Erin B. Dickerson, Erin B. Dickerson   +15 more
doaj   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources

Efficacy of Combined Topical Timolol and Oral Propranolol for Treating Infantile Hemangioma: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2020
BackgroundOral propranolol has become the first-line treatment for infantile hemangioma (IH). However, combined therapy with topical timolol and oral propranolol has been proposed as a more effective IH treatment strategy.
Junbo Qiao, Junjie Lin, Dexin Zhang, Junhua Li, Changkuan Chen, Hongye Yu, Xiaodi Li, Bin Fang   +7 more
doaj   +1 more source

Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study

Frontiers in Pediatrics, 2019
Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi ...
Luca Filippi, Giacomo Cavallaro, Lavinia Perciasepe, Elena Sandini, Gabriella Araimo, Giulia Regiroli, Giulia Regiroli, Genny Raffaeli, Paola Bagnoli, Massimo Dal Monte, Maura Calvani, Pina Fortunato, Silvia Osnaghi, Salvatore De Masi, Fabio Mosca, Fabio Mosca   +15 more
doaj   +1 more source