Results 71 to 80 of about 19,655 (167)

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P‐Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley   +1 more source

Continuous delivery of propranolol from liposomes-in-microspheres significantly inhibits infantile hemangioma growth

, 2017
Xiaonan Guo,1,* Xiaoshuang Zhu,1,* Dakan Liu,1 Yubin Gong,1 Jing Sun,2 Changxian Dong1 1Department of Hemangioma and Vascular Malformation, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 2Department of Pharmacy ...
Liu DK, Zhu XS, Gong YB, Guo XN, Sun J, Dong CX   +5 more
core  

Nail Clubbing‐Associated With a Large Segmental Infantile Hemangioma of the Arm in a Patient With PHACES Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Although infantile hemangiomas (IH) are common vascular tumors of childhood, associated nail abnormalities are rare. We report a child with a large segmental IH of the upper limb with marked, ipsilateral nail clubbing, which gradually improved until the age of 7 years.
Stefan Blunder, Lisa Weibel, Nicole Knöpfel, Martin Theiler, Agnes Schwieger‐Briel, Isabelle Luchsinger   +5 more
wiley   +1 more source

Evaluating Neurodevelopmental Sequelae of Propranolol Use in Infantile Hemangioma: A Large‐Scale Population‐Based Study

JEADV Clinical Practice
Background Propranolol is widely adopted as the first‐line treatment for problematic infantile hemangioma (IH). Despite its efficacy and widespread use, concerns persist about potential long‐term neurodevelopmental risks, given propranolol′s ability to ...
Khalaf Kridin, Samer Kridin, Wisal Sawaed, Ralf J. Ludwig   +3 more
doaj   +1 more source

Sex‐related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea

Experimental Physiology, EarlyView.
Abstract The incidence and presentation of obstructive sleep apnoea, as well as hypertension and cardiovascular disease, have been reported to differ by sex. It is thus reasonable to propose mechanisms contributing to subsequent pathology differ by sex. This concept is supported from a pre‐pathological perspective, as sex differences have been observed
Dain W. Jacob, Sara E. Mascone, Natasha G. Boyes, Anna M. Gonsalves, Jacqueline K. Limberg   +4 more
wiley   +1 more source

Efficacy and safety of oral propranolol and topical timolol in the treatment of infantile hemangioma: a meta-analysis and systematic review

Frontiers in Pharmacology
BackgroundPropranolol, a nonselective β-blocker, is the first-line treatment for infantile hemangioma (IH). Topical timolol has recently been proposed as a novel IH treatment with fewer adverse effects.
Xiaoye Huang, Xiaoye Huang, Wenyue Si, Zhili Zou, Binyao Li, Yide Mu, Wei Zhong, Kaiying Yang   +7 more
doaj   +1 more source

Lower limb blood flow responses during higher‐ and lower‐load bilateral leg press exercise

Experimental Physiology, EarlyView.
Abstract The local blood flow response to resistance exercise (RE) is complicated by local muscular contractions and large swings in perfusion pressure. The magnitude of these responses might vary according to exercise intensity, number of sets and number of repetitions, and as a result, the local shear environment during RE remains uncharacterized. We
Eudoxia Zafiris, Jeremy. N. Cohen, Tania J. Pereira, Jason S. Au   +3 more
wiley   +1 more source

Propranolol withdrawal syndrome. [PDF]

Introduction. Propranolol, a non-selective beta-blocker widely used for the treatment of various cardiovascular diseases. However, its abrupt discontinuation can lead to withdrawal syndrome.This syndrome manifests as increased adrenergic sensitivity ...
Žemaitis, Augustinas,, Podčašinskytė, Kotryna,   +1 more
core   +1 more source

Retrospective Evaluation of an Oral Propranolol Delivery Strategy in 25 Cases of Infantile Hemangioma

Journal of Plastic and Reconstructive Surgery
Objectives: The majority of infantile hemangiomas shrink on their own, but when there is a chance of functional impairment, ulceration, or aesthetic issues, an active therapeutic intervention is needed.
Shinichi Ashizawa, Takanobu Kan, Shunsuke Takahagi, Mikio Kawai, Sayuri Toda, Yasumasa Iwasaki, Shuhei Karakawa, Michihiro Hide, Akio Tanaka   +8 more
doaj  

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source