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The proprotein convertases in health and disease

Qatar Foundation Annual Research Forum Volume 2012 Issue 1, 2012
Background: The mammalian proprotein convertases (PCs) constitute a family of nine secretory serine proteases related to bacterial subtilisin and yeast kexin. Seven of them (PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7) activate cellular and pathogen precursor proteins by cleavage at single or paired basic residues, while SKI-1/S1P and PCSK9 regulate ...
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Characterization of proADAMTS5 processing by proprotein convertases

The International Journal of Biochemistry & Cell Biology, 2009
ADAMTS5 (aggrecanase-2), a key metalloprotease mediating cartilage destruction in arthritis, is synthesized as a zymogen, proADAMTS5. We report a detailed characterization of the propeptide excision mechanism and demonstrate that it is a major regulatory step with unusual characteristics. Using furin-deficient cells and a furin inhibitor, we found that
Bon Hun Koo, J. Preston Alexander, Daniel R. McCulloch, Suneel S. Apte, Jean-Michel Longpré, Richard Leduc   +5 more
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Tissue distribution and processing of proSAAS by proprotein convertases [PDF]

Journal of Neurochemistry, 2001
The conversion of inactive precursor proteins into bioactive neuropeptides and peptide hormones involves regulated secretory proteins such as prohormone convertases PC1 and PC2. The neuroendocrine protein 7B2 represents a specific binding protein for PC2, and the protein proSAAS, which interacts with PC1, exhibits certain structural and functional ...
A. Cameron, Y. Fortenberry, M. Sayah, Iris Lindberg   +3 more
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Proprotein convertase subtilisin/kexin type 9 in kidney disease.

Nephrology, Dialysis and Transplantation, 2019
Chronic kidney disease (CKD) is associated with a substantially increased risk for the development of atherosclerotic cardiovascular (CV) disease. Accordingly, CV mortality is increased even in the earliest stages of CKD. In the general population and in
David Schmit, D. Fliser, T. Speer
semanticscholar   +1 more source

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system

Neuroscience and Biobehavioral Reviews, 2023
A. Bell, Josephin Wagner, Daniel B. Rosoff, F. Lohoff   +3 more
semanticscholar   +1 more source

The proprotein convertase furin in cancer: more than an oncogene

Oncogene, 2022
Zongsheng He, A. Khatib, J. Creemers
semanticscholar   +1 more source

The Proprotein Convertases, 20 Years Later

2011
The proprotein convertases (PCs) are secretory mammalian serine proteinases related to bacterial subtilisin-like enzymes. The family of PCs comprises nine members, PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9 (Fig. 3.1). While the first seven PCs cleave after single or paired basic residues, the last two cleave at non-basic residues ...
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Viral envelope glycoprotein processing by proprotein convertases

Antiviral Research, 2013
The proprotein convertases (PCs) are a family of nine mammalian enzymes that play key roles in the maintenance of cell homeostasis by activating or inactivating proteins via limited proteolysis under temporal and spatial control. A wide range of pathogens, including major human pathogenic viruses can hijack cellular PCs for their own purposes.
Pasquato Antonella, da Palma Joel Ramos, Galan Clara, Seidah Nabil G, Kunz Stefan   +4 more
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Curbing activation: proprotein convertases in homeostasis and pathology

The FASEB Journal, 2003
The proprotein convertases (PCs) are a seven-member family of endoproteases that activate proproteins by cleavage at basic motifs. Expression patterns for individual PCs vary widely, and all cells express several members. The list of substrates activated by PCs has grown to include neuropeptides, peptide hormones, growth and differentiation factors ...
Wim J.M. Van de Ven, John W.M. Creemers, Neil A. Taylor   +2 more
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Plasma proprotein convertase subtilisin/kexin type 9 concentration and recurrent cardiovascular events in patients with familial hypercholesterolemia.

European Journal of Preventive Cardiology, 2019
AIMS Familial hypercholesterolemia patients are characterized by early onset of coronary artery calcification and atherosclerosis, and high incidence of cardiovascular events.
Yexuan Cao, Huihui Liu, Jinglu Jin, Di Sun, Yuan-Lin Guo, N. Wu, Cheng-gang Zhu, R. Xu, Jing Sun, R. Santos, Jian‐Jun Li   +10 more
semanticscholar   +1 more source