Results 1 to 10 of about 27,707 (152)

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Cancer Reports, 2023
Background Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period.
Hayder M. Al‐kuraishy, Thabat J. Al‐Maiahy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El‐Saber Batiha   +6 more
doaj   +3 more sources

Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-β/ERK Signaling Pathway [PDF]

Cells
Colorectal cancer (CRC) remains one of the most lethal malignancies worldwide, with 5-fluorouracil (5-Fu) as a mainstay of treatment. However, intrinsic and acquired resistance to 5-Fu significantly limits therapeutic success.
Pratheesh Kumar Poyil, Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rafia Begum, Padmanaban Annaiyappa Naidu, Saravanan Thangavel, Khadija Alobaisi, Saud Azam, Fouad Al-Dayel, Khawla S. Al-Kuraya   +9 more
doaj   +2 more sources

Furin as a Novel Pan-Viral Therapeutic Target: Implications for Dengue and SARS-CoV-2 [PDF]

Viruses
Dengue virus (DENV) and SARS-CoV-2 are emerging viral pathogens that share overlapping clinical features, including fever, fatigue, and respiratory symptoms, complicating differential diagnosis in endemic regions.
Lina Shalaby, Yaman Al-Haneedi, Alaa Abdelhamid, Hadi Yassine, Mohamed M. Emara   +4 more
doaj   +2 more sources

Furin‐mediated protein processing in infectious diseases and cancer

Clinical and Translational Immunology, 2019
Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Daniel Sauter
exaly   +2 more sources

Maturation-deficient chikungunya virus elicits protective immune responses in a murine challenge model [PDF]

npj Vaccines
Maturation of chikungunya virus (CHIKV) particles is dependent on cleavage of the precursor glycoprotein p62 into the proteins E3 and E2 by the cellular protease furin.
Danillo Lucas Alves Esposito, Jhefferson Barbosa Guimarães, Benedito Antonio Lopes da Fonseca, Beate Mareike Kümmerer   +3 more
doaj   +2 more sources

FURIN Stimulates NOTCH2 and NOTCH3 Pathways, Leading to Return of Function in Aged Cells [PDF]

Life
Background: Aging is accompanied by a progressive decline in skeletal muscle regeneration, largely due to impaired myogenic differentiation. The proprotein convertase FURIN is a key protease responsible for activating several signaling molecules ...
Peter L. Elkin, Jiaxing Liu, Jisaiah T. Wheeler, Thomas M. Suchyna, Wilma A. Hofmann   +4 more
doaj   +2 more sources

Ribonucleotide reductase subunit M2 mediates the mTOR pathway to recruit furin endoprotease and promote maturation of dengue virus [PDF]

iScience
Summary: Dengue virus (DENV) maturation involves calcium-dependent endoprotease furin, which cleaves the precursor membrane (prM) into the M protein in the trans-Golgi network, facilitating the release of infectious virus.
Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara   +2 more
doaj   +2 more sources

Furin as target for suppression of mosquito-borne viruses [PDF]

Virology Journal
Background Mosquitoes are the main vectors of arboviruses, which infect millions of people every year. These viruses depend on host factors, such as the proprotein convertase furin, for replication.
Alejandra Centurión, Bodunrin Omokungbe, Markus Oberpaul, Ludwig Dersch, Sabrina Stiehler, Cross Chambers, Marcus Lechner, Tim Lüddecke, Andreas Vilcinskas, Torsten Steinmetzer, Kornelia Hardes   +10 more
doaj   +2 more sources

Furin Egress from the TGN is Regulated by Membrane‐Associated RING‐CH Finger (MARCHF) Proteins and Ubiquitin‐Specific Protease 32 (USP32) via Nondegradable K33‐Polyubiquitination

Advanced Science
Furin primarily localizes to the trans‐Golgi network (TGN), where it cleaves and activates a broad range of immature proproteins that play critical roles in cellular homeostasis, disease progression, and infection.
Yong-Hui Zheng
exaly   +2 more sources

The proprotein convertase furin in tumour progression [PDF]

International Journal of Cancer, 2017
Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Michele Bernasconi
exaly   +5 more sources