Results 31 to 40 of about 32,754 (167)
The association between plasma furin and cardiovascular events after acute myocardial infarction
BMC Cardiovascular Disorders, 2021 Background Furin is the key enzyme involved in the cleavage of pro-BNP and plays a critical role in the cardiovascular system through its involvement in lipid metabolism, blood pressure regulation and the formation of atheromatous plaques.
Zhi-Wei Liu +4 more
doaj +1 more source
Cardiology Plus, 2021 Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the underlying mechanisms, but no evidence supports this possibility.
Sheng-Qi Ma +10 more
doaj +1 more source
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. [PDF]
PLoS ONE, 2013 There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues
Sergey A Shiryaev +8 more
doaj +1 more source
A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +1 more source
Haematologica, 2010 Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli +7 more
doaj +1 more source
Cells, 2023 Genome-wide association studies have revealed an association between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. We investigated the mechanism through which rs17514846 modulates FURIN expression.
Wei Yang +3 more
doaj +1 more source
Emerging Microbes and Infections, 2022 Swine acute diarrhea syndrome coronavirus (SADS-CoV) was reported in China in 2017 and is a causative agent of porcine enteric disease. Recent studies indicate that cells from various hosts are susceptible to SADS-CoV, suggesting the zoonotic potential ...
Jinman Kim, Jaewon Yoon, Jung-Eun Park
doaj +1 more source
A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness
Neoplasia: An International Journal for Oncology Research, 2008 Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway.
Julia M. Coppola +3 more
doaj +1 more source
Identification of serpin determinants of specificity and selectivity for furin inhibition through studies of α1PDX (α1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimeras. [PDF]
, 2013 α1-Protease inhibitor Portland (α1PDX) is an engineered serpin family inhibitor of the proprotein convertase (PC), furin, that exhibits high specificity but limited selectivity for inhibiting furin over other PC family proteases.
Steven T. Olson (7930775) +3 more
core +6 more sources
Furin-Guided Intracellular 68Ga Nanoparticle Formation Enhancing Tumor MicroPET Imaging
, 2019 Positron-emission tomography (PET) is routinely used in the clinic for tumor imaging with ultrahigh sensitivity, but tumor-targeted PET imaging probes are quite few.
Yaling Liu (204231) +6 more
core +1 more source