Results 31 to 40 of about 27,727 (172)
Polyarginines Are Potent Furin Inhibitors [PDF]
Journal of Biological Chemistry, 2000 The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small nontoxic nanomolar inhibitors have been reported to date.
A, Cameron +3 more
openaire +2 more sources
PLoS ONE, 2010 Furin, a specialized endoproteinase, transforms proproteins into biologically active proteins. Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax.
Katarzyna Gawlik +6 more
doaj +1 more source
The role of furin in papillomavirus infection [PDF]
Future Microbiology, 2009 Papillomaviruses represent a medically important virus family. Infection with a high-risk human papillomavirus type is a prerequisite for cervical carcinoma development. Infection by low-risk types may result in the generation of benign skin warts. It was recently found that infectious entry of these viruses is dependent upon a specific proteolytic ...
Patricia M, Day, John T, Schiller
openaire +2 more sources
Scientific Reports, 2018 Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin +8 more
doaj +1 more source
The association between plasma furin and cardiovascular events after acute myocardial infarction
BMC Cardiovascular Disorders, 2021 Background Furin is the key enzyme involved in the cleavage of pro-BNP and plays a critical role in the cardiovascular system through its involvement in lipid metabolism, blood pressure regulation and the formation of atheromatous plaques.
Zhi-Wei Liu +4 more
doaj +1 more source
Cells, 2023 Genome-wide association studies have revealed an association between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. We investigated the mechanism through which rs17514846 modulates FURIN expression.
Wei Yang +3 more
doaj +1 more source
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. [PDF]
PLoS ONE, 2013 There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues
Sergey A Shiryaev +8 more
doaj +1 more source
Cardiology Plus, 2021 Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the underlying mechanisms, but no evidence supports this possibility.
Sheng-Qi Ma +10 more
doaj +1 more source
A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness
Neoplasia: An International Journal for Oncology Research, 2008 Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway.
Julia M. Coppola +3 more
doaj +1 more source
A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +1 more source