Results 11 to 20 of about 32,754 (167)

Influence of organic solvents on the furin activity

The Ukrainian Biochemical Journal, 2018
Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk, O. V. Shybyryn, A. V. Semyroz, V. K. Kibirev   +3 more
doaj   +2 more sources

Cerebral furin deficiency causes hydrocephalus in mice

Genes and Diseases
Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice.
Shiqi Xie, Xiaoyong Xie, Jing Tang, Biao Luo, Jian Chen, Qixin Wen, Jianrong Zhou, Guojun Chen   +7 more
doaj   +2 more sources

Furin as a Novel Pan-Viral Therapeutic Target: Implications for Dengue and SARS-CoV-2 [PDF]

Viruses
Dengue virus (DENV) and SARS-CoV-2 are emerging viral pathogens that share overlapping clinical features, including fever, fatigue, and respiratory symptoms, complicating differential diagnosis in endemic regions.
Lina Shalaby, Yaman Al-Haneedi, Alaa Abdelhamid, Hadi Yassine, Mohamed M. Emara   +4 more
doaj   +2 more sources

Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-β/ERK Signaling Pathway [PDF]

Cells
Colorectal cancer (CRC) remains one of the most lethal malignancies worldwide, with 5-fluorouracil (5-Fu) as a mainstay of treatment. However, intrinsic and acquired resistance to 5-Fu significantly limits therapeutic success.
Pratheesh Kumar Poyil, Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rafia Begum, Padmanaban Annaiyappa Naidu, Saravanan Thangavel, Khadija Alobaisi, Saud Azam, Fouad Al-Dayel, Khawla S. Al-Kuraya   +9 more
doaj   +2 more sources

Maturation-deficient chikungunya virus elicits protective immune responses in a murine challenge model [PDF]

npj Vaccines
Maturation of chikungunya virus (CHIKV) particles is dependent on cleavage of the precursor glycoprotein p62 into the proteins E3 and E2 by the cellular protease furin.
Danillo Lucas Alves Esposito, Jhefferson Barbosa Guimarães, Benedito Antonio Lopes da Fonseca, Beate Mareike Kümmerer   +3 more
doaj   +2 more sources

FURIN Stimulates NOTCH2 and NOTCH3 Pathways, Leading to Return of Function in Aged Cells [PDF]

Life
Background: Aging is accompanied by a progressive decline in skeletal muscle regeneration, largely due to impaired myogenic differentiation. The proprotein convertase FURIN is a key protease responsible for activating several signaling molecules ...
Peter L. Elkin, Jiaxing Liu, Jisaiah T. Wheeler, Thomas M. Suchyna, Wilma A. Hofmann   +4 more
doaj   +2 more sources

Furin as target for suppression of mosquito-borne viruses [PDF]

Virology Journal
Background Mosquitoes are the main vectors of arboviruses, which infect millions of people every year. These viruses depend on host factors, such as the proprotein convertase furin, for replication.
Alejandra Centurión, Bodunrin Omokungbe, Markus Oberpaul, Ludwig Dersch, Sabrina Stiehler, Cross Chambers, Marcus Lechner, Tim Lüddecke, Andreas Vilcinskas, Torsten Steinmetzer, Kornelia Hardes   +10 more
doaj   +2 more sources

Xenon Gas Inhibits the Enzyme Furin In Vitro [PDF]

, 2020
: Aims: Certain cancers, pathogenic infections, and other diseases are facilitated by the host enzyme furin, a calcium-dependent serine protease that is the most prominent member of the family of proprotein convertases.
David, Beihl
core   +1 more source

Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.

, 2018
OBJECTIVE: Genome-wide association studies have revealed a robust association between genetic variation on chromosome 15q26.1 and coronary artery disease (CAD) susceptibility; however, the underlying biological mechanism is still unknown.
Bairu Chen (7754546), Tom R. Webb (7692185), David G. McVey (7692176), Xu Yang (112496), Wei Yang (109917), Catherine Andreadi (7687598), Peng Gong (69507), Nilesh J. Samani (7579793), Shu Ye (44563), Jingchun Wu (3157542), Guojun Zhao (3133605), Junhui Chen (743463)   +11 more
core   +7 more sources

1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

JCI Insight, 2023
Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-
Han Xie, Isinsu Bastepe, Wen Zhou, Birol Ay, Zara Ceraj, Ignacio A. Portales-Castillo, Eva S. Liu, Sherri-Ann M. Burnett-Bowie, Harald Jüppner, Eugene P. Rhee, Murat Bastepe, Petra Simic   +11 more
doaj   +1 more source