Results 21 to 30 of about 32,754 (167)

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris

Microbial Cell Factories, 2018
Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang, Yanyu Long, Suhuan Li, Ting Lin, Jingwen Wu, Yafei Zhang, Yao Lin   +6 more
doaj   +1 more source

A second functional furin site in the SARS-CoV-2 spike protein

Emerging Microbes and Infections, 2022
The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional
Yue Zhang, Li Zhang, Jiajing Wu, Yuanling Yu, Shuo Liu, Tao Li, Qianqian Li, Ruxia Ding, Haixin Wang, Jianhui Nie, Zhimin Cui, Yulin Wang, Weijin Huang, Youchun Wang   +13 more
doaj   +1 more source

Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury

Biomolecules, 2023
Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh   +5 more
doaj   +1 more source

Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis

Journal of Ovarian Research, 2021
Background Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS.
Yongqian Chen, Jintian Miao, Ge Lou
doaj   +1 more source

Furin-dependent priming of spike at the plasma membrane promotes antibody-mediated cell-cell fusion.

, 2023
(A) Immunoblots of shedded S1 subunits, IgG Hc collected from supernatants; or full-length spike, S1, S2 and cleaved S2’ and IgG Hc collected from HEK293T cell lysates expressing WT or R685A spike mutant, stimulated without or with 12.5 nM CB6 antibody ...
Yunyi Li (12980582), Xiaoxian Cui (1710616), Dianfan Li (8606073), Jiabin Mou (17373750), Guangxun Meng (480502), Shi Yu (3350138), Xu Zheng (296676), Yanqiu Zhou (2172931), Yuhui Gao (4382473), Yapei Zhao (526931), Min Chen (147733), Yuying Yang (4111534), Tingting Li (10553), Bingjie Zhou (4570981), Dimitri Lavillette (232360)   +14 more
core   +1 more source

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

PLoS ONE, 2010
Furin, a specialized endoproteinase, transforms proproteins into biologically active proteins. Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax.
Katarzyna Gawlik, Albert G Remacle, Sergey A Shiryaev, Vladislav S Golubkov, Mingxing Ouyang, Yingxiao Wang, Alex Y Strongin   +6 more
doaj   +1 more source

Insights into Omicron’s Low Fusogenicity through Molecular Studies on Spike-Furin Interactions

Bioinformatics and Biology Insights, 2023
The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its subvariants have a unique set of mutations. Two of those mutations (N679 K and P681 H) reside close to the S1 /S2 furin cleavage site (FCS; 685-686).
Spencer Mark Mondol, Md Hasib, Md. Belayet Hasan Limon, A S M Rubayet Ul Alam   +3 more
doaj   +1 more source

Synthesis and investigation of the derivatives of amidinohydrazonelated aromatic compounds as furin inhibitors [PDF]

, 2017
The proprotein convertase furin plays a crucial role in a variety of pathogenic processes such as cancer, bacterial and viral diseases, neurodegenerative disorders and diabetes. Thus, furin inhibitors are promi­sing therapeutics for the treatment of many
A. V. Semyroz, O. V. Shybyryn, null null, V. K. Kibirev, T. V. Osadchuk   +4 more
core   +1 more source

Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Scientific Reports, 2018
Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin, Eric Hay, Augustin Latourte, Thomas Funck-Brentano, Wafa Bouaziz, Hang-Korng Ea, Abdel-Majid Khatib, Pascal Richette, Martine Cohen-Solal   +8 more
doaj   +1 more source

FURIN (furin (paired basic amino acid cleaving enzyme)) [PDF]

, 2012
Review on FURIN (furin (paired basic amino acid cleaving enzyme)), with data on DNA, on the protein encoded, and where the gene is ...
Khatib, AM, Sfaxi, F
core   +1 more source