Results 21 to 30 of about 27,727 (172)
Frontiers in Immunology, 2021 The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis.
Zsuzsanna Ortutay +6 more
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FURIN and placental syncytialisation: a cautionary tale [PDF]
Cell Death & Disease, 2021 AbstractFURIN is a pro-protein convertase previously shown to be important for placental syncytialisation (Zhou et al. [1]), a process of cell fusion whereby placental cytotrophoblast cells fuse to form a multinucleated syncytium. This finding has been broadly accepted however, we have evidence suggesting the contrary. Spontaneously syncytialising term
Saije K. Morosin +4 more
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1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
JCI Insight, 2023 Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-
Han Xie +11 more
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A second functional furin site in the SARS-CoV-2 spike protein
Emerging Microbes and Infections, 2022 The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional
Yue Zhang +13 more
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Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury
Biomolecules, 2023 Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato +5 more
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Microbial Cell Factories, 2018 Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang +6 more
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Insights into Omicron’s Low Fusogenicity through Molecular Studies on Spike-Furin Interactions
Bioinformatics and Biology Insights, 2023 The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its subvariants have a unique set of mutations. Two of those mutations (N679 K and P681 H) reside close to the S1 /S2 furin cleavage site (FCS; 685-686).
Spencer Mark Mondol +3 more
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Journal of Ovarian Research, 2021 Background Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS.
Yongqian Chen, Jintian Miao, Ge Lou
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Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network [PDF]
Journal of Cell Science, 2008 Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling and trafficking of membrane proteins.
Jinbo, Han +3 more
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FURIN (furin (paired basic amino acid cleaving enzyme)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FURIN (furin (paired basic amino acid cleaving enzyme)), with data on DNA, on the protein encoded, and where the gene is implicated.
Khatib, AM, Sfaxi, F
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