Results 261 to 270 of about 38,575 (293)
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Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer.
Biochimica et biophysica acta. Reviews on cancer, 2021Anindita Bhattacharya +3 more
semanticscholar +1 more source
Pleiotropic effects of proprotein convertase subtilisin/kexin type 9 inhibitors?
Current Opinion in Lipidology, 2018Purpose of review Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol.
T. Filippatos +2 more
semanticscholar +1 more source
Proprotein convertase activation of aggrecanases in cartilage in situ
Archives of Biochemistry and Biophysics, 2008Proteolytic degradation of the major cartilage macromolecules, aggrecan and type II collagen, is a key pathological event in osteoarthritis (OA). ADAMTS-4 and ADAMTS-5, the primary aggrecanases capable of cartilage aggrecan cleavage, are synthesized as latent enzymes and require prodomain removal for activity.
Stella Markosyan +8 more
openaire +3 more sources
The proprotein convertases in the murine small intestine [PDF]
, 2008 The small intestine (SI) is a major endocrine organ with over 40 precursor hormones produced and proteolytically matured into active peptide hormones which signal throughout the body including the pancreas and CNS. One group of enzymes believed to be responsible for this maturation is the family of protein convertases (PCSKs).
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What lies ahead for the proprotein convertases?
Annals of the New York Academy of Sciences, 2011Limited proteolysis of secretory proteins is performed by one or more of the nine‐membered proprotein convertase (PC) family: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI‐1/S1P, and PCSK9. The first seven proteinases cleave proproteins at single or pairs of basic residues in the Golgi, secretory granules, cell surface, or endosomes.
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Proprotein Convertases in Tumorigenesis, Angiogenesis and Metastasis
2007Proprotein convertases (PCs) are directly responsible for the activation of protein precursors implicated in neoplasia by either the degradation of extracellular matrix and modulation of cell adhesion, growth and/or survival. These functions are crucial in the acquisition of the tumorigenic phenotype, tumor progression and metastasis. Here we discuss a
Geraldine Siegfried +2 more
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Proprotein Convertase Subtilisin/Kexin-Type 9 and Lipid Metabolism.
Advances in Experimental Medicine and Biology, 2020Shoudong Guo +3 more
semanticscholar +1 more source
Mouse Models of Human Proprotein Convertase Insufficiency
Endocrine Reviews, 2021Iris Lindberg
exaly
Proprotein Convertase 1/3 Deficiency
The Indian Journal of Pediatrics, 2017Gurinder Kumar +2 more
openaire +2 more sources