Results 121 to 130 of about 28,272 (264)
Aging Cell, Volume 25, Issue 1, January 2026.This article supports that ANGPTL4 secreted factor is induced transcriptionally and activated by proteolytic cleavage during senescence, contributing to the production of a pro‐inflammatory SASP. In the senescent cell microenvironment, ANGPTL4 could thus contribute to senescence‐dependent alterations such as inflammation and tumor initiation.
Gabriela Makulyte +20 more
wiley +1 more source
Атеросклероз, 2015 The review presents the current data of scientific literature about different phases of clinical trials of monoclonal antibodies against the proprotein convertase subtilisin/kexin type 9 (PCSK9). The results of completed clinical trials and the review of
K. S. Astrakova +3 more
doaj
The role of proprotein convertase subtilisin/kexin type 9 inhibitors in managing cardiovascular risk
South African Family Practice, 2016 Hypercholesterolaemia and dyslipidaemia, marked by decreased levels of high-density lipoprotein and elevated levels of lowdensity lipoprotein (LDL), increase the risk of cardiovascular disease.
Natalie Schellack +2 more
doaj +1 more source
Traditsioonilised ja uued ravimid aterogeense düslipideemia ravis [PDF]
, 2016 Kardiovaskulaarse riski kahandamise põhialuseks on LDL-kolesterooli sisalduse vähendamine. Statiinid on näidanud hulgalistes juhuslikustatud kliinilistes uuringutes tõhusust ja ohutust ning on muutunud sellega aterogeense düslipideemia valikravimiks ...
Viigimaa, Margus
core +2 more sources
Addressing unmet needs for chronic kidney disease treatment in type 1 diabetes: A review
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 16-26, January 2026.Abstract Chronic kidney disease (CKD) is a serious complication occurring in nearly one of three people with type 1 diabetes (T1D). Major therapeutic advances have been made in the management of CKD for people with type 2 diabetes (T2D), thereby improving their kidney, cardiovascular, and survival outcomes.
Katherine R. Tuttle +3 more
wiley +1 more source
Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furintype proprotein convertases [PDF]
, 2010 journal ...
KEINO-MASU Kazuko +3 more
core +1 more source
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies. [PDF]
, 2015 Congenital diarrhoeal disorders (CDDs) represent an evolving web of rare chronic enteropathies, with a typical onset early in life. In many of these conditions, severe chronic diarrhoea represents the primary clinical manifestation, whereas in others ...
BERNI CANANI, ROBERTO +4 more
core +1 more source
Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms
BioMed Research International, Volume 2026, Issue 1, 2026.Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder that significantly increases cardiovascular disease (CVD) risk in women. While insulin resistance and dyslipidemia are established contributors, growing evidence highlights mitochondrial dysfunction and chronic low‐grade inflammation as central drivers of cardiovascular ...
Olabimpe Caroline Badejogbin +8 more
wiley +1 more source
Journal of Lipid Research, 2007 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism.
Mark J. Graham +6 more
doaj +1 more source