Results 61 to 70 of about 313,411 (354)
Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Brief Overview [PDF]
The American Journal of Medicine, 2017 Proprotein convertase subtilisin/kexin type 9 inhibitors serve as a valuable addition to the armamentarium of lipid-lowering agents and have promising potential. By inhibiting the proprotein convertase subtilisin/kexin type 9 enzyme, this novel molecule leads to increased low-density lipoprotein receptor density and decreased circulation of low-density
Zachary R. Noel, Craig J. Beavers
openaire +3 more sources
Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]
, 2017 No abstract ...
Packard, Chris J.
core +1 more source
Diabetes Care, 2021 OBJECTIVE Dyslipidemia observed in type 2 diabetes (T2D) is atherogenic. Important features of diabetic dyslipidemia are increased levels of triglyceride-rich lipoproteins and small dense LDL particles, which all have apolipoprotein B100 (apoB100) as a ...
B. Vergès +8 more
semanticscholar +1 more source
Informatics in Medicine Unlocked, 2022 Hypercholesterolemia is a potential cardiovascular hazard that requires immediate therapeutic intervention. Research has shown that 3-Hydroxy-3-methylglutaryl- CoA reductase (HMG CoA reductase) and Proprotein convertase subtilisin/kexin type 9 (PCSK9 ...
Precious A. Akinnusi +8 more
doaj
HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox". [PDF]
, 2016 BackgroundProprotein convertase subtilisin kexin 9 (PCSK9) inhibitors reduce low-density lipoprotein cholesterol (LDL-C) and improve outcomes in the general population.
Deeks, Steven +10 more
core +1 more source
Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea. [PDF]
, 2021 Proprotein convertase 1/3 (PC1/3), encoded by the PCSK1 gene, is expressed in neuronal and (entero)endocrine cell types, where it cleaves and hence activates a number of protein precursors that play a key role in energy homeostasis.
Aerts, Laetitia +6 more
core +1 more source
Liver international (Print), 2021 Proprotein convertase subtilisin/kexin type 9 (PCSK9) controls blood cholesterol levels by fostering the LDL receptor (LDLR) degradation in hepatocytes.
Dafne Jacome Sanz +7 more
semanticscholar +1 more source
Mon.Not.Roy.Astron.Soc. 263 (1993) 781, 1993 The F0 V star 9 Aur A exhibits an irregular variability of amplitude $\approx $0.1 magnitude at optical wavelengths. The variations are too slow for it to be a $\delta$ Scuti-type star. There is no evidence for a close, interacting companion or ring of dust, either from infrared, ultraviolet, or speckle data.
arxiv +1 more source
PCSK9 induces a pro-inflammatory response in macrophages [PDF]
, 2018 Intraplaque release of inflammatory cytokines from macrophages is implicated in atherogenesis by inducing the proliferation and migration of media smooth muscle cells (SMCs). PCSK9 is present and released by SMCs within the atherosclerotic plaque but its
Adorni, Maria Pia +12 more
core +3 more sources
PCSK9 Biology and Its Role in Atherothrombosis [PDF]
, 2021 It is now about 20 years since the first case of a gain-of-function mutation involving the as-yet-unknown actor in cholesterol homeostasis, proprotein convertase subtilisin/kexin type 9 (PCSK9), was described.
Barale, Cristina +3 more
core +1 more source