Results 61 to 70 of about 16,388 (147)
Journal of Lipid Research, 2012 Successful development of drugs against novel targets crucially depends on reliable identification of the activity of the target gene product in vivo and a clear demonstration of its specific functional role for disease development.
Elena Fattori +10 more
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Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Introduction Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer.
Md. Wahidul Islam +6 more
wiley +1 more source
Vascular Calcification: Mechanisms, Models, and Therapies
iNew Medicine, Volume 2, Issue 2, June 2026.ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu +5 more
wiley +1 more source
Атеросклероз, 2015 The review presents the current data of scientific literature about different phases of clinical trials of monoclonal antibodies against the proprotein convertase subtilisin/kexin type 9 (PCSK9). The results of completed clinical trials and the review of
K. S. Astrakova +3 more
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The role of proprotein convertase subtilisin/kexin type 9 inhibitors in managing cardiovascular risk
South African Family Practice, 2016 Hypercholesterolaemia and dyslipidaemia, marked by decreased levels of high-density lipoprotein and elevated levels of lowdensity lipoprotein (LDL), increase the risk of cardiovascular disease.
Natalie Schellack +2 more
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Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li +10 more
wiley +1 more source
Journal of Lipid Research, 2010 Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation ...
Jeffrey D. Browning, Jay D. Horton
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Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
Frontiers in Cardiovascular MedicineProprotein convertase subtilisin/kexin type 9 (PCSK9) is a pivotal regulator of lipid metabolism and a validated therapeutic target in cardiovascular disease (CVD). While its canonical role in mediating low-density lipoprotein receptor (LDLR) degradation
Hang Su +10 more
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Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4975-4990, June 2026.ABSTRACT Aims To evaluate the association between semaglutide 2.4 mg and major adverse cardiovascular events (MACE) among adults with clinical atherosclerotic cardiovascular disease (ASCVD) and overweight/obesity without diabetes in real‐world clinical practice.
Michael G. Nanna +10 more
wiley +1 more source