Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors [PDF]
Canadian Medical Association Journal, 2019 PCSK9 is a protease that degrades hepatic LDL-C receptors. Evolocumab and alirocumab are fully human monoclonal antibodies administered as subcutaneous injections that inhibit PCSK9, preserving receptor availability to clear circulating LDL-C.[1][1],[2][2] In randomized, placebo-controlled ...
Derek, Leong, Peter E, Wu
openaire +2 more sources
Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa +5 more
wiley +1 more source
Untersuchungen zu der Entstehung und der Bedeutung löslicher Fragmente der neuralen Zelladhäsionsmoleküle NCAM und L1 im Zentralen Nervensystem der Maus [PDF]
, 2005 Zahlreiche Transmembranproteine existieren auch als lösliche Fragmente, die durch regulierte Prozessierung der extrazellulären Domäne dieser Moleküle entstehen.
Kalus, Ina +1 more
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FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Scientific Reports, 2017 In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in
Edward R. Smith +3 more
doaj +1 more source
Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells [PDF]
, 2021 Zsuzsanna Ortutay +5 more
openalex +1 more source
ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen +10 more
wiley +1 more source
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]
, 2005 Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
core +2 more sources
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis [PDF]
, 2021 Susanne Feder +7 more
openalex +1 more source
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.Punica granatum peel extract is rich in phenolic compounds, exhibits strong antioxidant activity, and modulates the expression of PCSK9 and LDL receptors. Collectively, these findings suggest a potential cardioprotective effect of the extract. ABSTRACT Lipoprotein metabolism is regulated by several key proteins, notably proprotein convertase subtilisin/
Raja Chaaba +9 more
wiley +1 more source
Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Cells, 2020 Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown. Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients, localization ...
Samuel Röhl +8 more
doaj +1 more source