Results 101 to 110 of about 18,795 (277)

LC‐DAD‐MSn and HR‐LC‐QTOF analysis of Ziziphus budhensis leaves and evaluation of their in vitro and in vivo biological activities

Chemistry &Biodiversity, Accepted Article.
Ziziphus budhensis is a species described in 2015 in Nepal poorly studied for its phytochemical composition and possible bioactivities. In this study, six extracts were obtained from Z. budhensis leaves using ultrasound assisted extraction with solvents in increasing polarity.
Samjhana Bharati, Binita Maharjan, Timila Shrestha, Shyam Sharan Shrestha, Stefania Sut, Hari Prasad Devkota, Ram Lal Swagat Shrestha, Stefano Dall'Acqua   +7 more
wiley   +1 more source

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

Journal of Lipid Research, 2021
In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the ...
Nabil G. Seidah
doaj  

PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype

Cells, 2019
During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype.
Franck Rodet, Alice Capuz, Bilgehan-Aybike Ozcan, Rémy Le Beillan, Antonella Raffo-Romero, Firas Kobeissy, Marie Duhamel, Michel Salzet   +7 more
doaj   +1 more source

The Proprotein Convertase PC7 [PDF]

Journal of Biological Chemistry, 2011
The zymogen activation mechanism and physiological functions of the most ancient and highly conserved basic amino acid-specific proprotein convertase 7 (PC7) are not known. Herein, we characterized the biosynthesis, subcellular localization, and trafficking of the membrane-bound full-length rat and human PC7. The prosegment of PC7 is primarily secreted
Nabil G. Seidah, Josée Hamelin, Estelle Rousselet, Maryssa Canuel, Suzanne Benjannet   +4 more
openaire   +3 more sources

Coronary Plaque Characteristics Assessed by Optical Coherence Tomography and Plasma Lipoprotein(a) Levels in Patients With Acute Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation is not fully understood. Aims This study seeks to explore the impact of Lp(a) levels on plaque morphology as assessed by OCT in a very high‐risk subset of patients ...
Francesca Maria Di Muro, Maria Federica Crociani, Giulia Nardi, Niccolo' Ciardetti, Lucrezia Biagiotti, Elisa Bigi, Francesco Meucci, Miroslava Stolcova, Francesca Ristalli, Emanuele Cecchi, Iacopo Muraca, Renato Valenti, Carlo Di Mario, Alessio Mattesini   +13 more
wiley   +1 more source

Label-Free Electrochemical Test of Protease Interaction with a Peptide Substrate Modified Gold Electrode

Chemosensors, 2021
Efficient deposition of biomolecules on the surface, maintaining their full activity and stability, is a most significant factor in biosensor construction.
Anna Wcisło, Izabela Małuch, Paweł Niedziałkowski, Tadeusz Ossowski, Adam Prahl   +4 more
doaj   +1 more source

PCSK‐9 Inhibitors Can Significantly Improve the Coronary Slow Flow Caused by Elevated Lipoprotein (a) in ST‐Elevation Myocardial Infarction Patients With Chronic Kidney Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary slow flow and no reflow significantly predict poor prognosis in acute myocardial infarction (AMI) patients, especially those with chronic kidney disease (CKD). Early identification of factors contributing to these conditions can mitigate ischemic events and improve outcomes.
Hao Xu, Ziqing Wang, Dan Chen, Haojie Zhang, Junhua Ge, Jian Li   +5 more
wiley   +1 more source

Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development [PDF]

, 2019
The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.
Forte, Maurizio, Marchitti, Simona, Rubattu, Speranza, Volpe, Massimo   +3 more
core   +1 more source

Proprotein convertase genes in Xenopus development [PDF]

Developmental Dynamics, 2005
AbstractProprotein convertases (PCs) are a family of serine endoproteases that proteolytically activate many precursor proteins within various secretory pathway compartments. Loss‐of‐function studies have demonstrated a critical role for these proteases in embryonic patterning and adult homeostasis, yet little is known about how substrate selectivity ...
Sylvia Nelsen, Jan L. Christian, Crispin Wong, Linnea K. Berg   +3 more
openaire   +3 more sources

Carboxy-Terminal Conversion of Profibrillin to Fibrillin at a Basic Site by PACE/Furin-Like Activity Required for Incorporation in the Matrix [PDF]

, 1999
Fibrillin-1, the main component of 10-12 nm microfibrils of the extracellular matrix, is synthesized as profibrillin and proteolytically processed to fibrillin.
Hamstra, Daniel, Milewicz, Dianna M., Park, Eun-Sook, Peters, Reiner, Putnam, Elizabeth A., Raghunath, Michael, Rehemtulla, Alnawaz, Ritty, Timothy, Tschödrich-Rotter, Mathias   +8 more
core   +1 more source