Results 101 to 110 of about 5,923 (228)
Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Cells, 2020 Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown. Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients, localization ...
Samuel Röhl +8 more
doaj +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Chronic kidney disease (CKD) is a significant public health challenge in Australia, affecting ~10% of the adult population and contributing to substantial morbidity and mortality. Diabetes, hypertension, cardiovascular disease and CKD frequently co‐exist; therefore, a multidisciplinary approach is necessary to manage these ...
M. P. Schlaich +7 more
wiley +1 more source
Furin‐mediated protein processing in infectious diseases and cancer
Clinical & Translational Immunology, 2019 Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, Daniel Sauter
doaj +1 more source
Influence of organic solvents on the furin activity
The Ukrainian Biochemical Journal, 2018 Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk +3 more
doaj +1 more source
Untersuchungen zu der Entstehung und der Bedeutung löslicher Fragmente der neuralen Zelladhäsionsmoleküle NCAM und L1 im Zentralen Nervensystem der Maus [PDF]
, 2005 Zahlreiche Transmembranproteine existieren auch als lösliche Fragmente, die durch regulierte Prozessierung der extrazellulären Domäne dieser Moleküle entstehen.
Kalus, Ina +1 more
core +1 more source
Experimental Physiology, EarlyView.Abstract Current literature on the metabolic effects of long‐distance hiking is limited to case studies with discrepant findings, and no prior studies have examined the role of diet in shaping these outcomes. In this study, we investigated changes in lipid profiles and dietary factors among 12 participants who completed the Colorado Trail.
Kiaya Johnston +3 more
wiley +1 more source
, 2014 Employs a literature review to describe intrinsic motivation as the force behind pro-social behavior, or when individuals willingly engage in behavior that is costly to them but benefits others.
Brock, J. Michelle +2 more
core +1 more source
Variant Prioritization by Pedigree‐Based Haplotyping
Genetic Epidemiology, Volume 50, Issue 3, April 2026.ABSTRACT Whole genome sequence (WGS) data provides opportunities for comprehensive evaluation of variants that may influence complex traits. However, prioritizing the large number of variants, particularly those in non‐coding regions, is a challenge.
Rafael A. Nafikov +8 more
wiley +1 more source
The Role of Proprotein Convertases in Upper Airway Remodeling. [PDF]
Mol Cells, 2022 Lee SN, Yoon JH.
europepmc +1 more source
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease [PDF]
, 2016 To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect failure of the cell to manage ...
Dolfe, Lisa
core +1 more source