Results 121 to 130 of about 18,795 (277)

Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters [PDF]

, 1999
Ajoy Basak, Sam F. Cooper, Andrée G. Roberge, Upen K. BANIK, Michel Chrètien, Nabil G. Seidah   +5 more
openalex   +2 more sources

Influence of organic solvents on the furin activity

The Ukrainian Biochemical Journal, 2018
Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk, O. V. Shybyryn, A. V. Semyroz, V. K. Kibirev   +3 more
doaj   +1 more source

Pathogenic Epitopes of Autoantibodies in Pemphigus Reside in the Amino-Terminal Adhesive Region of Desmogleins Which Are Unmasked by Proteolytic Processing of Prosequence [PDF]

, 2009
Pemphigus targets desmogleins (Dsgs), which are thought to be synthesized as inactive precursor proteins with prosequences that are cleaved by substilisin-like proprotein convertases, such as furin, to yield mature adhesive molecules.
Amagai, Masayuki, Hachiya, Takahisa, Ishii, Ken, Kuroda, Keiko, Saleh, Marwah Adly, Stanley, John R., Yokouchi, Mariko   +6 more
core   +1 more source

Associations Between Lipids and Lipid‐Lowering Drug Target Genes and Osteomyelitis: A Mendelian Randomization Analysis

Medicine Advances, EarlyView.
In this study, we identified several SNPs in PCSK9 as genetic tools to comprehensively assess the influential role of PCSK9 in CHD, CRP, and osteomyelitis. PCSK9 is associated with a lower risk of osteomyelitis, and PCSK9 is also associated with a reduction in CRP concentrations. Our study supports the notion that WC may be a potential mediator between
Zhiyi Zhou, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Wanzhe Liao, Yahan Li, Linghui Liu, Ziyuan Lu   +8 more
wiley   +1 more source

Furin‐mediated protein processing in infectious diseases and cancer

Clinical & Translational Immunology, 2019
Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, Daniel Sauter
doaj   +1 more source

Functional analysis of the MERS-coronavirus spike protein [PDF]

, 2014
Zehn Jahre nach dem Ausbruch des Severe Acute Respiratory Syndrome Coronavirus, SARS-CoV, ist ein neues Betacoronavirus, das Middle East Respiratory Syndrome Coronavirus, MERS-CoV, auf der arabischen Halbinsel entdeckt worden.
Gierer, Stefanie
core  

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

Obesity, EarlyView.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Nicholas Clarke, Alan P. Watt   +6 more
wiley   +1 more source

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Journal of Medicinal Chemistry, 2010
Furin belongs to the family of proprotein convertases (PCs) and is involved in numerous normal physiological and pathogenic processes, such as viral propagation, bacterial toxin activation, cancer, and metastasis.
Gero L. Becker, F. Sielaff, M. Than, I. Lindberg, S. Routhier, R. Day, Yinghui Lu, W. Garten, T. Steinmetzer   +8 more
semanticscholar   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

The Role of Proprotein Convertases in Upper Airway Remodeling. [PDF]

Mol Cells, 2022
Lee SN, Yoon JH.
europepmc   +1 more source