Results 121 to 130 of about 8,088 (248)

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis [PDF]

, 2020
Robert P. Giugliano, Terje R. Pedersen, Jeffrey L. Saver, Peter S. Sever, Anthony Keech, Erin A. Bohula, Sabina A. Murphy, Scott M. Wasserman, Narimon Honarpour, Huei Wang, Armando Lira Pineda, Marc S. Sabatine, on behalf of the FOURIER Investigators   +12 more
openalex   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder that significantly increases cardiovascular disease (CVD) risk in women. While insulin resistance and dyslipidemia are established contributors, growing evidence highlights mitochondrial dysfunction and chronic low‐grade inflammation as central drivers of cardiovascular ...
Olabimpe Caroline Badejogbin, Mary Olaoluwa Agunloye, Ojichukwuka Ebere Chijioke-Agu, Makinde Vincent Olubiyi, Success Oluwanifesimi Olugbuyiro, Olaniyi Azeez Soetan, Opeyemi Abel Bamgbose, Tobi Opeyemi Olaleye, Swaran J. S. Flora   +8 more
wiley   +1 more source

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Background Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the
Junchi Guo, Fang Huang, Peihan Lu, Meijuan Lu, Arquimedes Gasparotto Junior   +4 more
wiley   +1 more source

The Efficacy and Safety of Four Novel PCSK9 Monoclonal Antibodies in Patients With Hypercholesterolemia: A Systematic Review With Network Meta‐Analysis and Trial Sequential Analysis

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Aim This network meta‐analysis (NMA) evaluated four novel proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies for hypercholesterolemia management, comparing their lipid‐lowering efficacy and safety. Methods We systematically identified randomized controlled trials employing the frequentist NMA method to assess reductions in low ...
Sihua Wang, Chenyu Li, Duncong Fan, Arquimedes Gasparotto Junior   +3 more
wiley   +1 more source

Structural and functional analyses of the shedding protease ADAM17 in HoxB8-Immortalized macrophages and dendritic-like cells [PDF]

, 2018
A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, and ligands of the epidermal growth factor receptor.
Arnold, Philipp, Boss, Melanie, Cabron, Anne-Sophie, Dobert, Jan Philipp, El azzouzi, Karim, Linder, Stefan, Pavlenko, Egor, Renné, Thomas, Rosas, Marcela, Rose-John, Stefan, Schumacher, Neele, Schwarz, Jeanette, Taylor, Philip R., Zunke, Friederike   +13 more
core   +2 more sources

Bioinformatics-Aided Venomics

Toxins, 2015
Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well as ...
Quentin Kaas, David J. Craik
doaj   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 Induces Platelet‐Derived Transforming Growth Factor‐β to Promote Myocardial Fibrosis After Myocardial Infarction

Human Mutation, Volume 2026, Issue 1, 2026.
Aims The recovery of cardiac function after acute myocardial infarction is crucial for the prognosis of patients with myocardial infarction. Proprotein convertase subtilisin/Kexin Type 9 (PCSK9) inhibitors are widely used in patients with acute myocardial infarction due to their potent low‐density lipoprotein‐lowering effects. Recent studies have shown
Qianyun Wang, Wenxiang Huang, Dianmin Xia, Feifei Wang, Sujit Nair   +4 more
wiley   +1 more source

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

Nature Communications
Receptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin and related proprotein convertases, raising ...
Manon Bulliard, Katarina Pinjusic, Laura Iacobucci, Céline Schmuziger, Nadine Fournier, Daniel B. Constam   +5 more
doaj   +1 more source

Proprotein convertase subtisilin/kexin 9 levels decline with hepatitis C virus therapy in people with HIV/hepatitis C virus and correlate with inflammation [PDF]

, 2023
Malini Gandhi, Kim-Lien Nguyen, Jordan E. Lake, Dan Liao, Aleen Khodabakhshian, Mario Guerrero, Chrisandra Shufelt, C. Noel Bairey Merz, Wilbert Jordan, Eric S. Daar, Debika Bhattacharya, Kara W Chew   +11 more
openalex   +1 more source