Results 131 to 140 of about 18,795 (277)
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel +18 more
wiley +1 more source
Journal of Clinical Investigation, 2008 The proprotein convertases (PCs) are implicated in the activation of various precursor proteins that play an important role in tumor cell metastasis.
N. Scamuffa +8 more
semanticscholar +1 more source
Aging Cell, EarlyView.In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu +3 more
wiley +1 more source
Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9
Journal of Lipid Research, 2021 Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors (LDLRs). Plasma PCSK9 has 2 main molecular forms: a 62 kDa mature form (PCSK9_62) and a 55 kDa,
Carlota Oleaga +8 more
doaj
Biochemical characterization of proopiomelanocortin variants in human and owls [PDF]
, 2015 In humans the proopiomelanocortin (POMC) gene is located on the short arm of the chromosome 2 at the 23.3 position and encodes a 39kDa peptide with 241 amino acids. This peptide is the precursor of the proopiomelanocortin prohormone and it is produced in
SAINT-ROCH, A.
core
Genetic Determinants of the Familial Hypercholesterolaemia Phenotype
Annals of Human Genetics, EarlyView.ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley +1 more source
Toxins, 2015 Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well as ...
Quentin Kaas, David J. Craik
doaj +1 more source
Substrate Specificity of the Widely Expressed Subtilisin-like Proprotein Convertases (SPCs): A Role for the Substrate Amino Acid Directly Downstream of the Endoproteolytic Cleavage Site [PDF]
, 2001 Substrate specificity was investigated among four of the eukaryotic, widely expressed subtilisin-like proprotein convertases (SPCs): furin, PACE4, PC5, and PC7.
Tippett, Larry D.
core
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis [PDF]
, 1993 MK Schafer +5 more
openalex +1 more source
Pathogenic Deep Intronic PCSK1 Variant Causes Proprotein Convertase 1/3 Deficiency in a Family
Clinical Genetics, EarlyView.Biallelic PCSK1 loss‐of‐function mutations cause proprotein convertase 1/3 (PC1/3) deficiency, a polyendocrinopathy; a total of 36 patients were reported. The first deep intronic PCSK1 variant, (NM_000439.5):c.1196+2681T>A, was found to segregate with the disease in a consanguineous family, and is shown together with 32 reported mutations.
Leah M. Huber +6 more
wiley +1 more source