Results 141 to 150 of about 18,795 (277)
The proteolytic cleavage of SEMA3F may be mediated by non-furin proprotein convertases [PDF]
, 2016 Class III Semaphorins (SEMA3) comprise a family of chemokines that have been implicated as negative regulators of axonal guidance, angiogenesis and tumor progression.
Li, Erik
core +1 more source
cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. [PDF]
, 1996 Nabil G. Seidah +7 more
openalex +1 more source
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
Frontiers in Bioscience, 2008 The members of the proprotein convertase family play a central role in the processing and/or activation of various protein precursors involved in many physiological processes and various pathologies.
J. Creemers, A. Khatib
semanticscholar +1 more source
Diabetic Medicine, EarlyView.Abstract Aims Diabetes mellitus remains a prevalent condition worldwide and a significant risk factor for atherosclerotic cardiovascular disease. Recent evidence suggests the use of glucose‐lowering therapies with cardiovascular benefit in optimising the cardiometabolic profile of patients with type 2 diabetes mellitus.
Muhammad Usman Shah +6 more
wiley +1 more source
Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates [PDF]
, 2001 David J. Pearton +5 more
openalex +2 more sources
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. [PDF]
, 1996 Isabelle De Bie +6 more
openalex +1 more source
Polyphenols with indirect proprotein convertase inhibitory activity
International Journal of Oncology, 2013 Polyphenols, a class of natural products, have been shown to exhibit cancer protective properties. Proprotein convertases form a family of mammalian subtilisin-like serine endoproteases. Increased expression of these enzymes has been associated with numerous pathologies including cancer.
Wim J.M. Van de Ven +2 more
openaire +4 more sources
Nature CommunicationsReceptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin and related proprotein convertases, raising ...
Manon Bulliard +5 more
doaj +1 more source
Computational Modeling of Protein Dynamics with GROMACS and Java [PDF]
, 2012 GROMACS is a widely used package in molecular dynamics simulations of biological molecules such as proteins, and nucleic acids, etc. However, it requires many steps to run such simulations from the terminal window.
Yu, Miaoer
core +1 more source
Journal of Lipid Research, 2015 Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein,
Anna Roubtsova +7 more
doaj