Results 171 to 180 of about 18,795 (277)

Target‐Mediated Modeling of Alirocumab in Adolescents and Children ≥8 to <12 Years of Age Using Phase II and III Data

Clinical Pharmacology in Drug Development, Volume 14, Issue 5, Page 347-359, May 2025.
Abstract A population pharmacokinetic (PK) covariate analysis was conducted utilizing data from adolescents and children ≥8 to <12 years of age with heterozygous familial hypercholesterolemia. One phase II and 1 phase III study were analyzed (121 patients on active treatment).
Pavel Kovalenko, Lutz Harnisch, Jeanne Mendell, Yuhuan Wang, John D. Davis, Albert Thomas DiCioccio   +5 more
wiley   +1 more source

Proprotein Convertases in Tumor Progression and Malignancy [PDF]

, 2002
Abdel‐Majid Khatib, Géraldine Siegfried, Michel Chrètien, Peter Metrakos, Nabil G. Seidah   +4 more
openalex   +1 more source

Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis

Journal of Extracellular Biology, Volume 4, Issue 5, May 2025.
ABSTRACT Extracellular vesicles (EVs) are small particles released by various cells, including cancer cells. They play a significant role in the development of different cancers, including brain metastasis. These EVs transport biomolecular materials such as RNA, DNA, and proteins from tumour cells to other cells, facilitating the spread of primary ...
Muhammad Izhar, Maciej S. Lesniak
wiley   +1 more source

Biosynthetic Processing of the Pro-α1(V)2Pro-α2(V) Collagen Heterotrimer by Bone Morphogenetic Protein-1 and Furin-like Proprotein Convertases [PDF]

, 2002
Christine Unsöld, William N. Pappano, Yasutada Imamura, Barry M. Steiglitz, Daniel S. Greenspan   +4 more
openalex   +1 more source

Unraveling the relationship between head circumference and MC4R deficiency from infancy to adulthood: a case–control study

Obesity, Volume 33, Issue 5, Page 986-995, May 2025.
Abstract Objective The objective of this study was to investigate head circumference (HC) in patients with melanocortin 4 receptor (MC4R) deficiency, the most common cause of monogenetic obesity. Methods Patients with (likely) pathogenic MC4R variants were included.
Eline E. P. L. van der Walle, Cornelis J. de Groot, Lotte Kleinendorst, Hester de Klerk, Mila S. Welling, Ozair Abawi, Renate E. H. Meeusen, Mariëtte R. Boon, Elisabeth F. C. van Rossum, Mieke M. van Haelst, Erica L. T. van den Akker   +10 more
wiley   +1 more source

Development of selectivity of α1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition [PDF]

, 2002
Akihiko Tsuji, Takayuki Ikoma, Emi Hashimoto, Yoshiko Matsuda   +3 more
openalex   +1 more source

Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2573-2583, May 2025.
Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention and management of chronic kidney disease (CKD). Remnant cholesterol (RC), a lipoprotein with an established association with cardiovascular risk, has been investigated in the context of CKD.
Paschalis Karakasis, Dimitrios Patoulias, Manfredi Rizzo, Nikolaos Fragakis, Christos S. Mantzoros   +4 more
wiley   +1 more source

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation [PDF]

, 2003
Nabil G. Seidah, Suzanne Benjannet, L. Alexandra Wickham, Jadwiga Marcinkiewicz, Stéphanie Bélanger Jasmin, Stefano Stifani, Ajoy Basak, Annik Prat, Michel Chrètien   +8 more
openalex   +1 more source

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis [PDF]

, 2003
Géraldine Siegfried, Ajoy Basak, James A. Cromlish, Suzanne Benjannet, Jadwiga Marcinkiewicz, Michel Chrètien, Nabil G. Seidah, Abdel‐Majid Khatib   +7 more
openalex   +1 more source

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements [PDF]

, 2003
Bart De Cat, Sin-Ya Muyldermans, Christien Coomans, Gisèle Degeest, Bart Van der Schueren, John W.M. Creemers, Frédéric Biemar, Bernard Peers, Guido David   +8 more
openalex   +1 more source