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Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4

open access: bronze, 2009
Tetsuya Akamatsu   +5 more
openalex   +2 more sources
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The biology and therapeutic targeting of the proprotein convertases

Nature Reviews Drug Discovery, 2012
The mammalian proprotein convertases constitute a family of nine secretory serine proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or
Nabil G Seidah, Annik Prat
exaly   +5 more sources

Proprotein convertases in atherogenesis

Current Opinion in Lipidology, 2015
The proprotein convertases subtilisin/kexin (PCSKs) are endoproteases identified as activators of precursors from hormones and peptides. On the basis of the variety of substrates and regulation in disease, they have been recognized as mediators in atherogenesis.
P. Stawowy
openaire   +4 more sources

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