Results 241 to 250 of about 18,851 (272)

Curbing activation: proprotein convertases in homeostasis and pathology

The FASEB Journal, 2003
The proprotein convertases (PCs) are a seven-member family of endoproteases that activate proproteins by cleavage at basic motifs. Expression patterns for individual PCs vary widely, and all cells express several members. The list of substrates activated by PCs has grown to include neuropeptides, peptide hormones, growth and differentiation factors ...
Wim J.M. Van de Ven, John W.M. Creemers, Neil A. Taylor   +2 more
openaire   +3 more sources

Proprotein Convertases

Encyclopedia of Molecular Pharmacology, 2021
Andrés J. P. Klein Szanto, D. Bassi
semanticscholar   +1 more source

Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1.

Journal of Peptide Research, 2009
A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.
Ajoy Basak, Blair Ernst, Dyanne Brewer, Nabil G. Seidah, J. S. Munzer, C. Lazure, Gilles Lajoie   +6 more
semanticscholar   +1 more source

Proprotein convertase activation of aggrecanases in cartilage in situ

Archives of Biochemistry and Biophysics, 2008
Proteolytic degradation of the major cartilage macromolecules, aggrecan and type II collagen, is a key pathological event in osteoarthritis (OA). ADAMTS-4 and ADAMTS-5, the primary aggrecanases capable of cartilage aggrecan cleavage, are synthesized as latent enzymes and require prodomain removal for activity.
Stella Markosyan, Micky D. Tortorella, David W. Griggs, Nicholas R. Staten, Ruo-Hua Song, Elizabeth C. Arner, James T. Alston, Zhiyong Yang, Anne-Marie Malfait   +8 more
openaire   +3 more sources

The proprotein convertases in the murine small intestine [PDF]

, 2008
The small intestine (SI) is a major endocrine organ with over 40 precursor hormones produced and proteolytically matured into active peptide hormones which signal throughout the body including the pancreas and CNS. One group of enzymes believed to be responsible for this maturation is the family of protein convertases (PCSKs).
openaire   +2 more sources

Proprotein Convertases in Tumorigenesis, Angiogenesis and Metastasis

2007
Proprotein convertases (PCs) are directly responsible for the activation of protein precursors implicated in neoplasia by either the degradation of extracellular matrix and modulation of cell adhesion, growth and/or survival. These functions are crucial in the acquisition of the tumorigenic phenotype, tumor progression and metastasis. Here we discuss a
Geraldine Siegfried, Michel Chrétien, Abdel-Majid Khatib   +2 more
openaire   +2 more sources

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation

Current Opinion in Lipidology, 2018
N. Seidah, M. Chrétien, M. Mbikay
semanticscholar   +1 more source

Mouse Models of Human Proprotein Convertase Insufficiency

Endocrine Reviews, 2021
Iris Lindberg
exaly  

Proprotein Convertase Subtilisin/Kexin Type 9 and Inflammation: An Updated Review

Frontiers in Cardiovascular Medicine, 2022
Na-qiong Wu, Jian-jun Li
exaly  

Proprotein Convertase 1/3 Deficiency

The Indian Journal of Pediatrics, 2017
Gurinder Kumar, Rajendran Nair, Aman P. S. Sohal   +2 more
openaire   +2 more sources